Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis

• Published in: The Journal of immunology (1950) Vol. 199; no. 6; pp. 2128 - 2139
• Main Authors: Ahmed, Afsar U, Yim, Howard C H, Alorro, Mariah, Ernst, Matthias, Williams, Bryan R G
• Format: Journal Article
• Language: English
• Published: United States American Association of Immunologists 15.09.2017
• Subjects: 1-Phosphatidylinositol 3-kinase; Activation; Colitis; Colon; Dextran; Epithelium; ILK protein; Inflammatory bowel disease; Inflammatory bowel diseases; Intestine; Leukocytes (neutrophilic); Mice; Mucosa; Myeloid cells; NF-κB protein; Pathology; Rodents; Signal transduction; Sodium; Sodium sulfate; Stat3 protein; Sulfates

The pathology of inflammatory bowel diseases is driven by the inflammatory signaling pathways associated with mucosal epithelial damage. Myeloid cells are known to play an essential role in mediating epithelial inflammatory responses during injury. However, the precise role of these cells in stimula...