PGK1 is a Potential Survival Biomarker and Invasion Promoter by Regulating the HIF-1α–Mediated Epithelial-Mesenchymal Transition Process in Breast Cancer

• Published in: Cellular physiology and biochemistry Vol. 51; no. 5; pp. 2434 - 2444
• Main Authors: Fu, Deyuan, He, Chunlan, Wei, Jinli, Zhang, Zhengquan, Luo, Yulin, Tan, Haosheng, Ren, Chuanli
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2018; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: Bioinformatics; Biomarkers; Breast cancer; Cell adhesion & migration; Enzymes; Epithelial-mesenchymal transition; Gastric cancer; Gene expression; HIF-1α; Hypoxia; Kinases; Medical prognosis; Metabolism; Metastasis; Original Paper; Patients; PGK1; Tumors; United States > US; PGK1; Epithelial-mesenchymal transition; Breast cancer; HIF-1α

Background/Aims: Glycolysis, a multi-step enzymatic reaction, is considered to be the root of cancer development and progression. The aim of this study is to figure out which glycolysis enzyme participates in the progression of breast cancer and its possible mechanisms. Materials: We firstly screene...