CB2 Cannabinoid Receptors as a Therapeutic Target—What Does the Future Hold?

• Published in: Molecular pharmacology Vol. 86; no. 4; pp. 430 - 437
• Main Authors: Dhopeshwarkar, Amey, Mackie, Ken
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2014; The American Society for Pharmacology and Experimental Therapeutics
• Subjects: Animals; Cannabinoid Receptor Agonists - pharmacology; Cannabinoid Receptor Agonists - therapeutic use; Humans; Minireview; Pain - drug therapy; Protein Transport; Receptor, Cannabinoid, CB2 - agonists; Receptor, Cannabinoid, CB2 - genetics; Receptor, Cannabinoid, CB2 - metabolism; Signal Transduction; CP55940; AM1241; Δ9-THC; GPCR; CHO; WIN55212-2; GW842166X; MAPK; CB; ERK

The past decades have seen an exponential rise in our understanding of the endocannabinoid system, comprising CB1 and CB2 cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes that synthesize and degrade endocannabinoids. The primary focus of this review is the CB2 recep...