Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells - Schafer, Jolie R.; Salzillo, Travis C.; Chakravarti, Nitin; Kararoudi, Meisam Naeimi; Trikha, Prashant; Foltz, Jennifer A.; Wang, Ruoning; Li, Shulin; Lee, Dean A. (Journal of allergy and clinical immunology, 2019)
Keywords: Adenosine kinase; AMP; Cancer; Chlorophyll; Cytotoxicity; Education; Effector cells; Electron transport; Flow cytometry; Gene expression; Gene Expression Regulation - immunology; Glycolysis; Glycolysis - immunology; Histocompatibility antigen HLA; Human subjects; Humans; Immunoglobulins; Immunomodulation; Killer cell immunoglobulin-like receptors; Kinases; Licenses; Licensing; Ligands; Lymphocyte Activation - immunology; Metabolic pathways; Metabolism; Metabolites; Mitochondria; Models, Immunological; Natural killer cells; Peripheral blood; Phosphorylation; Protein kinase; Proteins; Proteomics; Pyruvate kinase; Pyruvic acid; Receptors, KIR - immunology; DSS; GLUT; PKM2; glycolysis; 2-DG; OXPHOS; RPPA; siRNA; MAPK; ECAR; NMR; APC; KIR; FISH; AMPK; metabolism; AICAR; Natural killer cells; CyTOF; NK; licensing; OCR