Sustained vascular endothelial growth factor delivery enhances angiogenesis and perfusion in ischemic hind limb

• Published in: Pharmaceutical research Vol. 22; no. 7; pp. 1110 - 1116
• Main Authors: Sun, Qinghua, Chen, Ruth R, Shen, Yuechun, Mooney, David J, Rajagopalan, Sanjay, Grossman, P Michael
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.07.2005
• Subjects: Actins - metabolism; Angiogenesis; Animals; Biocompatible Materials - administration & dosage; Capillaries - growth & development; Disease Models, Animal; Drug Carriers; Drug delivery systems; Hindlimb - blood supply; Hindlimb - physiopathology; Humans; Ischemia; Ischemia - drug therapy; Ischemia - physiopathology; Laboratory animals; Lactic Acid - administration & dosage; Laser-Doppler Flowmetry; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal - blood supply; Muscle, Skeletal - physiopathology; Neovascularization, Physiologic - drug effects; Perfusion; Platelet Endothelial Cell Adhesion Molecule-1 - metabolism; Polyglycolic Acid - administration & dosage; Polymers; Polymers - administration & dosage; Smooth muscle; Surgery; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - administration & dosage; Veins & arteries; Ann Arbor Michigan; United States > US; Michigan

We hypothesized that sustained delivery of vascular endothelial growth factor (VEGF) using a polymer [85:15 poly(lactide-co-glycolide) (PLG)] would enhance angiogenesis and improve perfusion of ischemic tissue. C57BL/6J mice (n = 20/group) underwent unilateral hind limb ischemia surgery and were ran...