The antimicrobial and osteoinductive properties of silver nanoparticle/poly ( dl -lactic- co- glycolic acid)-coated stainless steel

• Published in: Biomaterials Vol. 33; no. 34; pp. 8745 - 8756
• Main Authors: Liu, Yi, Zheng, Zhong, Zara, Janette N, Hsu, Chingyun, Soofer, Donnalisa E, Lee, Kevin S, Siu, Ronald K, Miller, Lloyd S, Zhang, Xinli, Carpenter, Doug, Wang, Chunling, Ting, Kang, Soo, Chia
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.12.2012
• Subjects: 3T3 Cells; Advanced Basic Science; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antimicrobial osteoinductive; Bacteria - drug effects; Bacterial Infections - drug therapy; Bacterial Infections - etiology; Coated Materials, Biocompatible - chemistry; Coated Materials, Biocompatible - pharmacology; Dentistry; Femur - diagnostic imaging; Femur - growth & development; Femur - microbiology; Implant-associated infections; Lactic Acid - chemistry; Male; Mice; Nanoparticles - chemistry; Osteoblasts - cytology; Osteogenesis; Poly(dl-lactic-co-glycolic acid) (PLGA); Polyglycolic Acid - chemistry; Prostheses and Implants - adverse effects; Radiography; Rats; Rats, Sprague-Dawley; Silver - chemistry; Silver - pharmacology; Silver nanoparticle; Silver nanoparticle/poly(dl-lactic-co-glycolic acid)-coated stainless steel alloy (SNPSA); Stainless Steel - chemistry; Poly( dl-lactic- co-glycolic acid) (PLGA); Antimicrobial osteoinductive; Silver nanoparticle/poly( dl-lactic- co-glycolic acid)-coated stainless steel alloy (SNPSA); Implant-associated infections; Silver nanoparticle; Silver nanoparticle/poly(dl-lactic-co-glycolic acid)-coated stainless steel alloy (SNPSA); Poly(dl-lactic-co-glycolic acid) (PLGA)
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/j.biomaterials.2012.08.010

Abstract Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. In this study, we evaluated s ilver n anoparticle/ p oly( dl -lactic- co- glycolic acid) (PLGA)-coated stainless s teel a lloy(SNPSA) as a potential antimicrobial implant material. We found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo , and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro . Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. Our results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery.