B-Cell Maturation Antigen (BCMA) as a Biomarker and Potential Treatment Target in Systemic Lupus Erythematosus

• Published in: International journal of molecular sciences Vol. 25; no. 19; p. 10845
• Main Authors: Martin, Jonas, Cheng, Qingyu, Laurent, Sarah A, Thaler, Franziska S, Beenken, Anne Elisabeth, Meinl, Edgar, Krönke, Gerhard, Hiepe, Falk, Alexander, Tobias
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.10.2024; MDPI
• Subjects: Adult; Antibodies; Antibodies, Antinuclear - blood; Antibodies, Antinuclear - immunology; Antibodies, Monoclonal, Humanized - pharmacology; Antibodies, Monoclonal, Humanized - therapeutic use; Antigens; B cells; B-Cell Activating Factor - blood; B-Cell Activating Factor - metabolism; B-Cell Maturation Antigen - immunology; B-Cell Maturation Antigen - metabolism; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - metabolism; B-Lymphocytes - drug effects; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; BAFF; BCMA; Biomarkers; Biomarkers - blood; Blood; Bone marrow; Case-Control Studies; Cell receptors; Cells; Development and progression; Drug therapy; Female; Flow cytometry; Health aspects; Humans; Lupus; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - drug therapy; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - metabolism; Male; Middle Aged; Multiple myeloma; Pathogenesis; Physiological aspects; Plasma; Prognosis; SLE; Systemic lupus erythematosus; TACI; Tumor necrosis factor; Tumor Necrosis Factor Ligand Superfamily Member 13 - blood; Tumor Necrosis Factor Ligand Superfamily Member 13 - metabolism; Tumor necrosis factor-TNF; Germany; BAFF; TACI; BCMA; B cells; plasma cells; SLE; lupus

The BAFF-APRIL system is crucial for the pathogenesis of systemic lupus erythematosus (SLE) by promoting B cell survival, differentiation and the maintenance of humoral autoimmunity. Here, we investigated the relationship of BCMA expression on B cell subsets with its ligands BAFF and APRIL, together...