Voltage-Gated Calcium Influx Modifies Cholinergic Inhibition of Inner Hair Cells in the Immature Rat Cochlea

• Published in: The Journal of neuroscience Vol. 38; no. 25; pp. 5677 - 5687
• Main Authors: Zachary, Stephen, Nowak, Nathaniel, Vyas, Pankhuri, Bonanni, Luke, Fuchs, Paul Albert
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 20.06.2018
• Subjects: Acetylcholine receptors (nicotinic); Calcium; Calcium channels; Calcium channels (L-type); Calcium channels (voltage-gated); Calcium conductance; Calcium influx; Calcium ions; Channels; Cochlea; Electric potential; Electron microscopy; Hair; Hair cells; Inhibition; Inhibitory postsynaptic potentials; Potassium; Potassium channels (calcium-gated); Potassium channels (voltage-gated); Potassium conductance; Receptors; Resistance; Rodents; Ryanodine; Sensory neurons; Synapses; ribbon synapse; synaptic cistern; L-type calcium channel; calcium-activated potassium channel; efferent inhibition; calcium-induced calcium release

Until postnatal day (P) 12, inner hair cells of the rat cochlea are invested with both afferent and efferent synaptic connections. With the onset of hearing at P12, the efferent synapses disappear, and afferent (ribbon) synapses operate with greater efficiency. This change coincides with increased e...