Functional Micro-Dispensers based on Micro-Electro-Mechanical-Systems (MEMS) integrated with fabrics as functional materials to protect humans from mosquito feeding

• Published in: Journal of controlled release Vol. 220; no. Pt A; pp. 1 - 4
• Main Authors: Bernier, Ulrich R., Gurman, Pablo, Clark, Gary G., Elman, Noel
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 28.12.2015
• Subjects: air; Animals; Bio- micro-electro-mechanical systems (BioMEMS); cost effectiveness; Culicidae; electronics; fabrics; Functional materials; Human trials; Humans; Insect Repellents - pharmacology; manufacturing; Micro-Electrical-Mechanical Systems; mosquito bites; permethrin; repellents; Textiles; Vector-borne diseases; Vector-borne diseases; Human trials; Bio- micro-electro-mechanical systems (BioMEMS); Functional materials
• ISSN: 0168-3659; 1873-4995
• DOI: 10.1016/j.jconrel.2015.09.049

Functional Micro-Dispensers (FMDs) based on Micro-Electro-Mechanical-Systems (MEMS) were designed to deliver spatial repellents that reduce the ability of mosquitoes to feed on humans. FMDs were integrated with fabrics as functional materials for protection against mosquito bites. The use of MEMS devices provides an unprecedented control over the release kinetics by means of integration with electronics for selective and timely activation of each device to perform controlled release of pesticides in air. In addition, because MEMS manufacturing techniques evolved from the microelectronic industry, FMDs can be mass produced at very low cost. Trials using FMDs that contained transfluthrin improved protection against mosquito feeding in human subjects above that of permethrin-treated uniform fabric worn on the arm of the volunteer. The overall reduction in feeding was approximately 90% compared to the untreated fabric control, and about 50% reduction compared to the permethrin-treated fabric control. The devices were efficacious over course of 32days. FMDs have the potential for a simple and cost-effective implementation for mass adoption as wearable devices integrated in fabrics as active functional materials. [Display omitted]