HIV coreceptors, cell tropism and inhibition by chemokine receptor ligands

• Published in: Molecular membrane biology Vol. 16; no. 1; pp. 49 - 55
• Main Authors: Clapham, Paul R., Reeves, Jacqueline D., Simmons, Graham, Dejucq, Natalie, Hibbitts, Sam, Aine, McKnight
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 1999; Taylor & Francis
• Subjects: CD4 Antigens - physiology; Hiv Tropism;Hiv Receptors; Humans; Models, Biological; Receptors, CCR5 - physiology; Receptors, Chemokine - physiology; Receptors, HIV - physiology; Tropism - physiology

HIV is a persistent virus that survives and replicates despite an onslaught by the host's immune system. A strategy for cell entry, requiring the use of two receptors, has evolved that may help evade neutralizing antibodies. HIV and SIV usually require both CD4 and a seven transmembrane (7TM) c...