Micromolar sodium fluoride promotes osteo/odontogenic differentiation in dental pulp stem cells by inhibiting PI3K/AKT pathway

• Published in: Archives of oral biology Vol. 131; p. 105265
• Main Authors: Xu, Shuaimei, Xie, Xinghuan, Li, Changzhou, Liu, Zhongjun, Zuo, Daming
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2021
• Subjects: Cell Differentiation; Cell Proliferation; Cells, Cultured; Dental Caries; Dental Pulp; Dental pulp stem cells; Humans; Odontogenesis; Osteogenesis; Phosphatidylinositol 3-Kinases; PI3K/AKT pathway; Proto-Oncogene Proteins c-akt; Sodium fluoride; Sodium Fluoride - pharmacology; Stem Cells; ARS; ALP; DMP1; Cell differentiation; DSPP; PI3K/AKT pathway; MSCs; NaF; DPSCs; RNA-seq; Dental pulp stem cells; KEGG; Sodium fluoride; GAPDH; BSP; OM

Sodium fluoride (NaF) plays an important role in preventing dental caries. However, the regulatory effect of NaF on the committed differentiation of DPSCs is not fully understood. In this study, we characterized the impact of micromolar levels of NaF on the osteo/odontogenic differentiation of DPSCs...