Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice

• Published in: The Journal of clinical investigation Vol. 99; no. 5; pp. 1064 - 1071
• Main Authors: Mould, A W, Matthaei, K I, Young, I G, Foster, P S
• Format: Journal Article
• Language: English
• Published: United States 01.03.1997
• Subjects: Adoptive Transfer; Animals; Biological Assay; Bone Marrow - drug effects; Bone Marrow Cells; Chemokine CCL11; Chemokines, CC; Chemotaxis - immunology; Chemotaxis - physiology; Cytokines - administration & dosage; Cytokines - pharmacology; Cytokines - physiology; Eosinophilia - genetics; Eosinophilia - immunology; Eosinophilia - pathology; Eosinophils - immunology; Hypersensitivity - immunology; Hypersensitivity - pathology; Inflammation - pathology; Interleukin-5 - administration & dosage; Interleukin-5 - genetics; Interleukin-5 - pharmacology; Interleukin-5 - physiology; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Skin - drug effects; Skin - immunology; Skin - pathology

The mechanism of cooperation between IL-5 and eotaxin for the selective accumulation of eosinophils at sites of allergic inflammation is unknown. In this investigation we have used IL-5 deficient mice to define the relationship between this cytokine and eotaxin in the regulation of blood eosinophili...