Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain

• Published in: Free radical biology & medicine Vol. 49; no. 11; pp. 1798 - 1803
• Main Authors: Owen, Joshua B., Sultana, Rukhsana, Aluise, Christopher D., Erickson, Michelle A., Price, Tulin O., Bu, Guojun, Banks, William A., Butterfield, D. Allan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2010
• Subjects: 4-Hydroxy-2-nonenal; Aged; Aged, 80 and over; Alzheimer disease; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amyloid beta-Peptides - metabolism; Amyloid β-peptide; Brain - metabolism; Brain - pathology; Case-Control Studies; Cognition - physiology; Female; Free radicals; Hippocampus - metabolism; Hippocampus - pathology; Humans; Lipid peroxidation; Low Density Lipoprotein Receptor-Related Protein-1 - metabolism; Low-density lipoprotein receptor-related protein 1; Male; Oxidation-Reduction; Oxidative stress; Protein Multimerization; Protein Transport - physiology; Oxidative stress; 4-Hydroxy-2-nonenal; Free radicals; Alzheimer disease; Lipid peroxidation; Low-density lipoprotein receptor-related protein 1; Amyloid β-peptide

Alzheimer disease (AD) is a neurodegenerative disorder characterized histopathologically by the presence of senile plaques (SPs), neurofibrillary tangles, and synapse loss. The main component of SPs is amyloid-β peptide (Aβ), which has been associated with increased oxidative stress, leading to oxid...