An increase in BAG-1 by PD-L1 confers resistance to tyrosine kinase inhibitor in non–small cell lung cancer via persistent activation of ERK signalling - Lin, Po-Lin; Wu, Tzu-Chin; Wu, De-Wei; Wang, Lee; Chen, Chi-Yi; Lee, Huei (European journal of cancer (1990), 2017)
Keywords: A549 Cells; Activation; Animals; Antibodies, Monoclonal - pharmacology; Antineoplastic Combined Chemotherapy Protocols - pharmacology; B7-H1 Antigen - antagonists & inhibitors; B7-H1 Antigen - genetics; B7-H1 Antigen - metabolism; BAG-1; Bcl-2-Like Protein 11 - metabolism; BIM; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - enzymology; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; CCAAT-Enhancer-Binding Protein-beta - metabolism; Cell death; Cell Movement - drug effects; Cells; Deletion; Disease-Free Survival; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Drug Resistance, Neoplasm; EGFR; Enzyme Activation; Enzyme inhibitors; Extracellular Signal-Regulated MAP Kinases - metabolism; Female; Gene Expression Regulation, Neoplastic; Humans; Inhibitors; Kinases; Lung cancer; Lung Neoplasms - drug therapy; Lung Neoplasms - enzymology; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Medical treatment; Mice, Inbred BALB C; Mice, Nude; Mutation; Neoplasm Invasiveness; Non-small cell lung carcinoma; NSCLC; PD-L1; PD-L1 protein; Phosphorylation; Polymerase chain reaction; Promoter Regions, Genetic; Protein Binding; Protein Kinase Inhibitors - pharmacology; Protein Stability; Quinazolines - pharmacology; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Receptor, Epidermal Growth Factor - genetics; Receptor, Epidermal Growth Factor - metabolism; RNA Interference; Signal Transduction - drug effects; Signaling; Studies; Time Factors; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription, Genetic; Transfection; Tumors; Tyrosine; Up-Regulation; Xenograft Model Antitumor Assays; PD-L1; NSCLC; BAG-1; EGFR; BIM