Delivery of RALA/siFKBPL nanoparticles via electrospun bilayer nanofibres: An innovative angiogenic therapy for wound repair

• Published in: Journal of controlled release Vol. 316; pp. 53 - 65
• Main Authors: Mulholland, Eoghan J., Ali, Ahlam, Robson, Tracy, Dunne, Nicholas J., McCarthy, Helen O.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 28.12.2019
• Subjects: alginates; Angiogenesis; Animals; blood vessels; Cell Line; cell movement; chitosan; crosslinking; cytotoxicity; Electrospinning; Gene Knockdown Techniques; Gene therapy; Gene Transfer Techniques; Genetic Therapy; Humans; Mice; Mice, Inbred C57BL; Nanofibers; Nanoparticles; Neovascularization, Physiologic - genetics; Particle Size; peptides; polyvinyl alcohol; ral GTP-Binding Proteins - genetics; RNA, Small Interfering - administration & dosage; siRNA; small interfering RNA; surfactants; Tacrolimus Binding Proteins - genetics; therapeutics; tissue repair; transfection; Wound healing; Wound Healing - genetics; zeta potential; Nanoparticles; Electrospinning; Angiogenesis; siRNA; Wound healing; Gene therapy

[Display omitted] FK506-binding protein-like (FKBPL) has previously been shown to inhibit angiogenesis viain vitro and in vivo experimentation. Thus, it was proposed that the delivery of a siRNA targeting FKBPL could hold great potential in promoting angiogenesis for advanced wound healing applicati...