Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 312; no. 6; pp. G550 - G558
• Main Authors: Ward, Joseph B. J., Lajczak, Natalia K., Kelly, Orlaith B., O’Dwyer, Aoife M., Giddam, Ashwini K., Ní Gabhann, Joan, Franco, Placido, Tambuwala, Murtaza M., Jefferies, Caroline A., Keely, Simon, Roda, Aldo, Keely, Stephen J.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.06.2017
• Subjects: Acids; Animals; Anti-Inflammatory Agents - pharmacology; Bacteria - metabolism; Bile; Bile acids; Biotransformation; Chromatography; Colitis - chemically induced; Colitis - metabolism; Colitis - microbiology; Colitis - prevention & control; Colon; Colon - drug effects; Colon - metabolism; Colon - microbiology; Colon - pathology; Cytokines - metabolism; Dextran; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial cells; Gas chromatography; Gastrointestinal Microbiome; HT29 Cells; Humans; Inflammation; Inflammation Mediators - metabolism; Inflammatory bowel diseases; Interferon; Interleukin 6; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Intestinal Mucosa - pathology; Intestine; Lithocholic Acid - pharmacology; Male; Mass spectrometry; Mass spectroscopy; Mice, Inbred C57BL; Mucosa; Rodents; Sodium; Sodium sulfate; Sulfate; Time Factors; Tumor necrosis factor-α; Ursodeoxycholic acid; Ursodeoxycholic Acid - analogs & derivatives; Ursodeoxycholic Acid - metabolism; Ursodeoxycholic Acid - pharmacology; γ-Interferon; cytokine; epithelium; bile acid; barrier function; inflammatory bowel disease

Inflammatory bowel diseases (IBD) comprise a group of common and debilitating chronic intestinal disorders for which currently available therapies are often unsatisfactory. The naturally occurring secondary bile acid, ursodeoxycholic acid (UDCA), has well-established anti-inflammatory and cytoprotec...