Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon - Ward, Joseph B. J.; Lajczak, Natalia K.; Kelly, Orlaith B.; O’Dwyer, Aoife M.; Giddam, Ashwini K.; Ní Gabhann, Joan; Franco, Placido; Tambuwala, Murtaza M.; Jefferies, Caroline A.; Keely, Simon; Roda, Aldo; Keely, Stephen J. (American journal of physiology: Gastrointestinal and liver physiology, 2017)
Keywords: Acids; Animals; Anti-Inflammatory Agents - pharmacology; Bacteria - metabolism; Bile; Bile acids; Biotransformation; Chromatography; Colitis - chemically induced; Colitis - metabolism; Colitis - microbiology; Colitis - prevention & control; Colon; Colon - drug effects; Colon - metabolism; Colon - microbiology; Colon - pathology; Cytokines - metabolism; Dextran; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial cells; Gas chromatography; Gastrointestinal Microbiome; HT29 Cells; Humans; Inflammation; Inflammation Mediators - metabolism; Inflammatory bowel diseases; Interferon; Interleukin 6; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Intestinal Mucosa - pathology; Intestine; Lithocholic Acid - pharmacology; Male; Mass spectrometry; Mass spectroscopy; Mice, Inbred C57BL; Mucosa; Rodents; Sodium; Sodium sulfate; Sulfate; Time Factors; Tumor necrosis factor-α; Ursodeoxycholic acid; Ursodeoxycholic Acid - analogs & derivatives; Ursodeoxycholic Acid - metabolism; Ursodeoxycholic Acid - pharmacology; γ-Interferon; cytokine; epithelium; bile acid; barrier function; inflammatory bowel disease