Response of peripheral blood basophils in subjects with chronic spontaneous urticaria during treatment with omalizumab

• Published in: Journal of allergy and clinical immunology Vol. 147; no. 6; pp. 2295 - 2304.e12
• Main Authors: MacGlashan, Donald, Saini, Sarbjit, Schroeder, John T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2021; Elsevier Limited
• Subjects: allergy; Anti-Allergic Agents - administration & dosage; Anti-Allergic Agents - adverse effects; Anti-Allergic Agents - therapeutic use; Antibodies; Asthma; auto-antibodies; Autoantibodies; Autoantibodies - blood; Autoantibodies - immunology; Basopenia; basophil; Basophils - drug effects; Basophils - immunology; Basophils - metabolism; Biomarkers; Chronic Urticaria - diagnosis; Chronic Urticaria - drug therapy; Chronic Urticaria - immunology; Food allergies; Genotype & phenotype; Histamine; Histamine Release; Human; Humans; Immunoglobulin E; Immunoglobulin E - immunology; Kinases; Laboratories; Leukocyte Count; Leukocytes (basophilic); Monoclonal antibodies; Omalizumab - administration & dosage; Omalizumab - adverse effects; Omalizumab - therapeutic use; Patients; Peripheral blood; Phenotypes; Protein-tyrosine kinase; Receptors, IgE - metabolism; Signal Transduction; Spleen; Syk Kinase - metabolism; Syk protein; Treatment Outcome; Urticaria; Human; CSU-NR; CSU; fMLP; SYK; signal transduction; PMA; uFcεRI; allergy; HR; basophil; pDC; auto-antibodies; MFI; PBB; AS; phenotypes; PE; BTK; EC50; tFcεRI; CSU-R
• ISSN: 0091-6749; 1097-6825; 1097-6825
• DOI: 10.1016/j.jaci.2021.02.039

Treatment of patients with asthma or food allergy with omalizumab results in several consistent changes in circulating basophils. The multiple basophil phenotypes observed in patients with chronic spontaneous urticaria (CSU) present some unique attributes that may not respond in a similar fashion to...