Dietary Insulinogenic Amino Acid Restriction Improves Glucose Metabolism in a Neonatal Piglet Model

• Published in: Nutrients Vol. 17; no. 10; p. 1675
• Main Authors: Gorton, Matthew W., Goodarzi, Parniyan, Lei, Xia, Anderson, Michael, Habibi, Mohammad, Wilson, Nedra, Pezeshki, Adel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.05.2025; MDPI
• Subjects: Amino acids; Amino Acids - administration & dosage; Amino Acids - deficiency; Animals; Animals, Newborn; Blood Glucose - metabolism; Dextrose; Diabetes; Diet; Diet - veterinary; Feeds; Glucose; Glucose - metabolism; Glucose Tolerance Test; Hogs; Insulin; Insulin - blood; Insulin Resistance; Insulin-like growth factors; Laboratory animals; Liver - metabolism; Male; Metabolism; Nutrition research; Physiological aspects; Proteins; Swine; Teenagers; Type 2 diabetes; New York; United States; Massachusetts; United States > US; Oklahoma; insulinogenic amino acids; insulin sensitivity; neonatal pigs; FGF-21 signaling; glucose metabolism

Background: Dietary consumption of insulinogenic amino acids (IAA) is known to contribute to the development of insulin resistance. It remains to be studied whether dietary IAA restriction improves glucose metabolism and insulin sensitivity and whether this improvement is related to alterations in g...