Reduced insulin secretion in normoglycaemic patients with β-thalassaemia major
Aims To assess insulin sensitivity and secretion in the fasting state in regularly transfused patients with β‐thalassaemia major with normal glucose response during an oral glucose tolerance test and to estimate its possible relation to iron overload. Methods We measured fasting glucose, insulin a...
Saved in:
Published in | Diabetic medicine Vol. 23; no. 12; pp. 1327 - 1331 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.12.2006
Blackwell |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Aims To assess insulin sensitivity and secretion in the fasting state in regularly transfused patients with β‐thalassaemia major with normal glucose response during an oral glucose tolerance test and to estimate its possible relation to iron overload.
Methods We measured fasting glucose, insulin and C‐peptide levels in 24 patients with β‐thalassaemia major and 18 control subjects matched for age and body mass index. Insulin sensitivity and insulin release index were calculated according to the homeostasis model assessment (HOMA). Correlations with age, body mass index and serum ferritin were also calculated.
Results Fasting glucose levels in patients were increased compared with control subjects (5.5 ± 0.12 vs. 4.7 ± 0.13 mmol/l, mean ± sem, P < 0.001). Pancreatic B‐cell insulin secretion in the fasting state (estimated by SCHOMA) was lower in thalassaemic patients (SCHOMA 88.5 ± 11.11 vs. 184.3 ± 23.72 in control subjects, P < 0.001). Patients were then divided into those with impaired (IFG) and normal (NFG) fasting glucose. SCHOMA was higher in the patients with NFG compared with those with IFG patients (110.6 ± 17.63 vs. 66.3 ± 10.88, respectively, P < 0.05) but estimated insulin sensitivity (ISIHOMA) was similar. Plasma values of C‐peptide correlated positively with ferritin (r = 0.42, P = 0.04) and SCHOMA (r = 0.45, P = 0.02) and negatively with ISIHOMA (r = −0.43, P = 0.03).
Conclusions These results support the concept that impaired B‐cell function, as reflected by a reduction in the insulin secretion index, is present in β‐thalassaemic patients with normoglycaemia before changes in oral glucose tolerance tests are apparent. |
---|---|
Bibliography: | istex:098F221578F2844CB162485207732D5AAD0B1DF8 ark:/67375/WNG-7D3SQVHK-K ArticleID:DME1988 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0742-3071 1464-5491 |
DOI: | 10.1111/j.1464-5491.2006.01988.x |