Diversity in Fibroblast Growth Factor Receptor 1 Regulation: Learning from the Investigation of Kallmann Syndrome

• Published in: Journal of neuroendocrinology Vol. 20; no. 2; pp. 141 - 163
• Main Authors: Kim, S.-H., Hu, Y., Cadman, S., Bouloux, P.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2008; Blackwell Science
• Subjects: anosmin-1; Biological and medical sciences; Cell Movement; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Endocrinopathies; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; FGFR1; Fundamental and applied biological sciences. Psychology; Gastrointestinal Hormones - metabolism; Genotype; GnRH; Gonadotropin-Releasing Hormone - metabolism; heparan sulphate; Heparitin Sulfate - metabolism; History, 19th Century; History, 20th Century; Humans; Hypothalamus. Hypophysis. Epiphysis (diseases); Kallmann syndrome; Kallmann Syndrome - genetics; Kallmann Syndrome - history; Kallmann Syndrome - metabolism; Kallmann Syndrome - physiopathology; Malformations of the nervous system; Medical sciences; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurology; Neurons - metabolism; Neuropeptides - metabolism; Non tumoral diseases; Non tumoral diseases. Target tissue resistance. Benign neoplasms; olfactory bulb; Otorhinolaryngology. Stomatology; Phenotype; Receptor, Fibroblast Growth Factor, Type 1 - genetics; Receptor, Fibroblast Growth Factor, Type 1 - metabolism; Receptors, G-Protein-Coupled - metabolism; Receptors, Peptide - metabolism; Signal Transduction; Vertebrates: endocrinology; Endocrinopathy; Hypogonadotropic hypogonadism; Fibroblast growth factor; Nervous system diseases; Hypothalamic diseases; Central nervous system; Gonadotropin RH; Kallmann syndrome; Encephalon; Genetic disease; Genital diseases; Cerebral disorder; Hypothalamic hormone; Growth factor receptor; Olfactory pathway; anosmin-1; Malformation; Central nervous system disease; heparan sulphate; ENT disease; Olfactory bulb; Hormone releasing factor; GnRH; FGFR1

The unravelling of the genetic basis of the hypogonadotrophic hypogonadal disorders, including Kallmann syndrome (KS), has led to renewed interest into the developmental biology of gonadotrophin‐releasing hormone (GnRH) neurones and, more generally, into the molecular mechanisms of reproduction. KS...