De Novo Design of Cell‐Penetrating Foldamers

• Published in: Chemical record Vol. 20; no. 9; pp. 912 - 921
• Main Authors: Yokoo, Hidetomo, Misawa, Takashi, Demizu, Yosuke
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2020
• Subjects: Amino acids; Amino Acids - chemistry; cell-penetrating peptide; Cell-Penetrating Peptides - chemistry; Cell-Penetrating Peptides - metabolism; DDS carrier; Drug Carriers - chemistry; foldamer; Humans; Membrane permeability; non-proteinogenic amino acid; Nucleic acids; Oligomers; Peptides; Peptides, Cyclic - chemistry; Peptoids - chemistry; Proline - chemistry; secondary structure; Urea - chemistry; secondary structure; DDS carrier; cell-penetrating peptide; non-proteinogenic amino acid; foldamer

Cell‐penetrating peptides (CPPs) have gained much attention as carriers of hydrophilic molecules, such as drugs, peptides, and nucleic acids, into cells. CPPs are mainly composed of cationic amino acid residues, which play an important role in their intracellular uptake via interactions with acidic...