De Novo Design of Cell‐Penetrating Foldamers
Cell‐penetrating peptides (CPPs) have gained much attention as carriers of hydrophilic molecules, such as drugs, peptides, and nucleic acids, into cells. CPPs are mainly composed of cationic amino acid residues, which play an important role in their intracellular uptake via interactions with acidic...
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| Published in | Chemical record Vol. 20; no. 9; pp. 912 - 921 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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United States
Wiley Subscription Services, Inc
01.09.2020
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| Abstract | Cell‐penetrating peptides (CPPs) have gained much attention as carriers of hydrophilic molecules, such as drugs, peptides, and nucleic acids, into cells. CPPs are mainly composed of cationic amino acid residues, which play an important role in their intracellular uptake via interactions with acidic groups on cell surfaces. In addition, the secondary structures of CPPs also affect their cell‐membrane permeability. Based on this knowledge, a variety of cell‐penetrating foldamers (oligomers that form organized secondary structures) have been developed to date. In this account, we describe recent attempts to develop cell‐penetrating foldamers containing various building blocks, and their application as DDS carriers. |
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| AbstractList | Cell‐penetrating peptides (CPPs) have gained much attention as carriers of hydrophilic molecules, such as drugs, peptides, and nucleic acids, into cells. CPPs are mainly composed of cationic amino acid residues, which play an important role in their intracellular uptake via interactions with acidic groups on cell surfaces. In addition, the secondary structures of CPPs also affect their cell‐membrane permeability. Based on this knowledge, a variety of cell‐penetrating foldamers (oligomers that form organized secondary structures) have been developed to date. In this account, we describe recent attempts to develop cell‐penetrating foldamers containing various building blocks, and their application as DDS carriers. Cell-penetrating peptides (CPPs) have gained much attention as carriers of hydrophilic molecules, such as drugs, peptides, and nucleic acids, into cells. CPPs are mainly composed of cationic amino acid residues, which play an important role in their intracellular uptake via interactions with acidic groups on cell surfaces. In addition, the secondary structures of CPPs also affect their cell-membrane permeability. Based on this knowledge, a variety of cell-penetrating foldamers (oligomers that form organized secondary structures) have been developed to date. In this account, we describe recent attempts to develop cell-penetrating foldamers containing various building blocks, and their application as DDS carriers.Cell-penetrating peptides (CPPs) have gained much attention as carriers of hydrophilic molecules, such as drugs, peptides, and nucleic acids, into cells. CPPs are mainly composed of cationic amino acid residues, which play an important role in their intracellular uptake via interactions with acidic groups on cell surfaces. In addition, the secondary structures of CPPs also affect their cell-membrane permeability. Based on this knowledge, a variety of cell-penetrating foldamers (oligomers that form organized secondary structures) have been developed to date. In this account, we describe recent attempts to develop cell-penetrating foldamers containing various building blocks, and their application as DDS carriers. |
| Author | Yokoo, Hidetomo Misawa, Takashi Demizu, Yosuke |
| Author_xml | – sequence: 1 givenname: Hidetomo surname: Yokoo fullname: Yokoo, Hidetomo organization: Yokohama City University, 1-7-29 – sequence: 2 givenname: Takashi surname: Misawa fullname: Misawa, Takashi email: misawa@nihs.go.jp organization: National Institute of Health Sciences, 3-25-26, Tonomachi – sequence: 3 givenname: Yosuke orcidid: 0000-0001-7521-4861 surname: Demizu fullname: Demizu, Yosuke email: demizu@nihs.go.jp organization: Yokohama City University, 1-7-29 |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32463155$$D View this record in MEDLINE/PubMed |
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| Keywords | secondary structure DDS carrier cell-penetrating peptide non-proteinogenic amino acid foldamer |
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| Snippet | Cell‐penetrating peptides (CPPs) have gained much attention as carriers of hydrophilic molecules, such as drugs, peptides, and nucleic acids, into cells. CPPs... Cell-penetrating peptides (CPPs) have gained much attention as carriers of hydrophilic molecules, such as drugs, peptides, and nucleic acids, into cells. CPPs... |
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| SubjectTerms | Amino acids Amino Acids - chemistry cell-penetrating peptide Cell-Penetrating Peptides - chemistry Cell-Penetrating Peptides - metabolism DDS carrier Drug Carriers - chemistry foldamer Humans Membrane permeability non-proteinogenic amino acid Nucleic acids Oligomers Peptides Peptides, Cyclic - chemistry Peptoids - chemistry Proline - chemistry secondary structure Urea - chemistry |
| Title | De Novo Design of Cell‐Penetrating Foldamers |
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