Colonization of the developing pancreas by neural precursors from the bowel

• Published in: Developmental dynamics Vol. 194; no. 2; pp. 142 - 154
• Main Authors: Kirchgessner, A. L., Adlersberg, M. A., Gershon, M. D.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.1992
• Subjects: Animals; Biomarkers; Cell Movement - physiology; Culture Techniques; Development; Enteric nervous system; Ganglia - chemistry; Ganglia - embryology; Gut; Immunohistochemistry; Intestines - embryology; Neural crest; Neural Crest - embryology; Neurons - physiology; Pancreas - chemistry; Pancreas - embryology; Pancreatic innervation; Phenotypic expression; Rats; Rats, Sprague-Dawley

Neurons in ganglia of the myenteric plexus of the duodenum and stomach have recently been demonstrated to innervate pancreatic ganglia and transsynaptically to excite acinar and islet cells. The hypothesis that crestderived cells first colonize the foregut and secondarily enter the pancreas by way o...