Bronchial responsiveness to methacholine and adenosine 5′-monophosphate in atopic and non-atopic preschool children with recurrent wheezing

• Published in: Clinical and experimental allergy Vol. 37; no. 1; pp. 15 - 21
• Main Authors: Kim, D. K., Choi, S. H., Yu, J., Yoo, Y., Koh, Y. Y.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2007; Blackwell
• Subjects: adenosine 5′-monophosphate (AMP); Adenosine Monophosphate; Allergic diseases; Area Under Curve; atopy; Auscultation; Biological and medical sciences; Bronchial Hyperreactivity - chemically induced; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Chi-Square Distribution; Child; Child, Preschool; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Hypersensitivity - physiopathology; Immunopathology; Male; Medical sciences; methacholine; Methacholine Chloride; preschool children; Recurrence; Respiratory Sounds; wheezing; Preschool age; Immunopathology; Allergy; Relapse; AMP; Bronchus; Wheezing; adenosine 5'-monophosphate (AMP); Respiratory system; Atopy; Respiratory tract; preschool children; Immunology; methacholine

Summary Background It is well known that atopy is a major determinant of bronchial hyper‐responsiveness (BHR) in both asymptomatic and asthmatic children. However, the relationship between atopy and BHR has not been well studied in preschool children with wheezing. BHR is usually measured by bronchi...