Association of IL23R p.381Gln and ATG16L1 p.197Ala with Crohn disease in the Czech population

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 49; no. 4; p. 405
• Main Authors: Dusatkova, Petra, Hradsky, Ondrej, Lenicek, Martin, Bronsky, Jiri, Nevoral, Jiri, Kotalova, Radana, Bajerova, Katerina, Vitek, Libor, Lukas, Milan, Cinek, Ondrej
• Format: Journal Article
• Language: English
• Published: United States 01.10.2009
• Subjects: Adult; Alleles; Autophagy-Related Proteins; Carrier Proteins - genetics; Case-Control Studies; Child; Crohn Disease - genetics; Czech Republic; Genome-Wide Association Study; Genotype; Humans; Phenotype; Polymorphism, Single Nucleotide; Receptors, Interleukin - genetics; Reference Values; Upper Gastrointestinal Tract

An association of variants in the genes encoding the interleukin 23 receptor (IL23R, p.Arg381Gln, rs11209026), and the autophagy-related gene 16-like 1 (ATG16L1, p.Ala197Thr, rs2241880) with Crohn disease (CD) was identified by whole genome association studies, and subsequently confirmed by other wo...