Selection of different 5′ untranslated region hepatitis C virus variants during post-transfusion and post-transplantation infection

• Published in: Journal of viral hepatitis Vol. 13; no. 7; pp. 489 - 498
• Main Authors: Gallegos-Orozco, J. F., Arenas, J. I., Vargas, H. E., Kibler, K. V., Wilkinson, J. K., Nowicki, M., Radkowski, M., Nasseri, J., Rakela, J., Laskus, T.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2006
• Subjects: 5' Untranslated Regions - genetics; Adult; Base Sequence; Female; Hepacivirus - genetics; Hepatitis C - etiology; Hepatitis C - virology; Hepatitis C virus; Humans; internal ribosomal entry site; Liver Transplantation - adverse effects; Middle Aged; Molecular Sequence Data; Nucleic Acid Conformation; Protein Biosynthesis; reverse transcriptase polymerase chain reaction; single-strand conformation polymorphism; Transfusion Reaction; translation efficiency; viral hepatitis

Background:  Hepatitis C virus (HCV) translation is initiated in a cap‐independent manner by an internal ribosome entry site (IRES) located within the 5′ untranslated region (5′UTR). Sequence changes in this region could affect translation efficiency and presumably viral replication. Aim:  To determ...