Serum interleukin 18 and tumour necrosis factor-α levels are increased in Behcet's disease

Summary Inflammation in Behcet's disease is thought to be mediated by cytokines derived from T‐helper type 1 (Th1) lymphocytes. In this study, we tried to determine serum interleukin (IL)‐18 and tumour necrosis factor (TNF)‐α levels of patients with Behcet's disease. Twenty‐seven patients...

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Published in	Clinical and experimental dermatology Vol. 30; no. 1; pp. 61 - 63
Main Authors	Oztas, M. O., Onder, M., Gurer, M. A., Bukan, N., Sancak, B.
Format	Journal Article
Language	English
Published	Oxford, UK Blackwell Science Ltd 01.01.2005 Blackwell
Subjects	Adult Behcet Syndrome - blood Biological and medical sciences Enzyme-Linked Immunosorbent Assay Female Humans Interleukin-18 - blood Male Medical sciences Middle Aged Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Tumor Necrosis Factor-alpha - metabolism Human Skin disease Stomatology Dermatology Cardiovascular disease Behçet syndrome Genital diseases Interleukin 18 Vascular disease Eye disease Vasculitis Systemic disease Serum Tumor necrosis factor α
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ISSN	0307-6938 1365-2230
DOI	10.1111/j.1365-2230.2004.01684.x

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Abstract	Summary Inflammation in Behcet's disease is thought to be mediated by cytokines derived from T‐helper type 1 (Th1) lymphocytes. In this study, we tried to determine serum interleukin (IL)‐18 and tumour necrosis factor (TNF)‐α levels of patients with Behcet's disease. Twenty‐seven patients with active Behcet's disease, and 20 healthy control subjects were included in this study. Differences between mean serum IL‐18 and TNF‐α level of patients with Behcet's disease were significantly increased when compared with the control group. A significant correlation was found between serum IL‐18 and TNF‐α levels of Behcet patients (rs = 0.627, P < 0.0001). IL‐18 and TNF‐α levels may be related to disease pathogenesis. Increased levels of IL‐18 also support Th1 predominance in Behcet's disease.
AbstractList	Summary Inflammation in Behcet's disease is thought to be mediated by cytokines derived from T‐helper type 1 (Th1) lymphocytes. In this study, we tried to determine serum interleukin (IL)‐18 and tumour necrosis factor (TNF)‐α levels of patients with Behcet's disease. Twenty‐seven patients with active Behcet's disease, and 20 healthy control subjects were included in this study. Differences between mean serum IL‐18 and TNF‐α level of patients with Behcet's disease were significantly increased when compared with the control group. A significant correlation was found between serum IL‐18 and TNF‐α levels of Behcet patients (rs = 0.627, P < 0.0001). IL‐18 and TNF‐α levels may be related to disease pathogenesis. Increased levels of IL‐18 also support Th1 predominance in Behcet's disease. Inflammation in Behcet's disease is thought to be mediated by cytokines derived from T-helper type 1 (Th1) lymphocytes. In this study, we tried to determine serum interleukin (IL)-18 and tumour necrosis factor (TNF)-alpha levels of patients with Behcet's disease. Twenty-seven patients with active Behcet's disease, and 20 healthy control subjects were included in this study. Differences between mean serum IL-18 and TNF-alpha level of patients with Behcet's disease were significantly increased when compared with the control group. A significant correlation was found between serum IL-18 and TNF-alpha levels of Behcet patients (rs = 0.627, P < 0.0001). IL-18 and TNF-alpha levels may be related to disease pathogenesis. Increased levels of IL-18 also support Th1 predominance in Behcet's disease.Inflammation in Behcet's disease is thought to be mediated by cytokines derived from T-helper type 1 (Th1) lymphocytes. In this study, we tried to determine serum interleukin (IL)-18 and tumour necrosis factor (TNF)-alpha levels of patients with Behcet's disease. Twenty-seven patients with active Behcet's disease, and 20 healthy control subjects were included in this study. Differences between mean serum IL-18 and TNF-alpha level of patients with Behcet's disease were significantly increased when compared with the control group. A significant correlation was found between serum IL-18 and TNF-alpha levels of Behcet patients (rs = 0.627, P < 0.0001). IL-18 and TNF-alpha levels may be related to disease pathogenesis. Increased levels of IL-18 also support Th1 predominance in Behcet's disease. Inflammation in Behcet's disease is thought to be mediated by cytokines derived from T-helper type 1 (Th1) lymphocytes. In this study, we tried to determine serum interleukin (IL)-18 and tumour necrosis factor (TNF)-alpha levels of patients with Behcet's disease. Twenty-seven patients with active Behcet's disease, and 20 healthy control subjects were included in this study. Differences between mean serum IL-18 and TNF-alpha level of patients with Behcet's disease were significantly increased when compared with the control group. A significant correlation was found between serum IL-18 and TNF-alpha levels of Behcet patients (rs = 0.627, P < 0.0001). IL-18 and TNF-alpha levels may be related to disease pathogenesis. Increased levels of IL-18 also support Th1 predominance in Behcet's disease.
Author	Bukan, N. Gurer, M. A. Sancak, B. Oztas, M. O. Onder, M.
Author_xml	– sequence: 1 givenname: M. O. surname: Oztas fullname: Oztas, M. O. organization: Departments of Dermatology and Biochemistry, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey – sequence: 2 givenname: M. surname: Onder fullname: Onder, M. organization: Departments of Dermatology and Biochemistry, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey – sequence: 3 givenname: M. A. surname: Gurer fullname: Gurer, M. A. organization: Departments of Dermatology and Biochemistry, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey – sequence: 4 givenname: N. surname: Bukan fullname: Bukan, N. organization: Departments of Dermatology and Biochemistry, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey – sequence: 5 givenname: B. surname: Sancak fullname: Sancak, B. organization: Departments of Dermatology and Biochemistry, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey
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Cites_doi	10.1080/09629350220131935 10.1007/s002960050091 10.1038/386619a0 10.1016/0140-6736(90)92643-V 10.1002/art.10815 10.1086/515313 10.1016/S0022-1759(97)00094-X 10.1080/030097402320318387
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References	Evans CA, Jellis J, Hughes SP et al. Tumour necrosis factor-alpha, interleukin-6, and interleukin-8 secretion and the acute phase response in patients with bacterial and tuberculous osteomyelitis. J Infect Dis 1998; 177: 1582-7. Evereklioglu C, Er H, Turkoz Y, Cekmen M. Serum levels of TNF-alpha, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behcet's disease. Med Inflamm 2002; 11: 87-93.DOI: 10.1080/09629350220131935 Ghayur T, Banerjee S, Hugunin M et al. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 1997; 386: 619-23.DOI: 10.1038/386619a0 Behcet H. Ueber rezidiverende aphtoese, durch ein virus verur sachte Geschwuere am mund am Auge und an den Genitalien. Dermatol Wochenschr 1937; 105: 1152. Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's disease. Lancet 1990; 335: 1078-80. Hamzaoui K, Hamzaoui A, Guemira F et al. Cytokine profile in Behcet's disease patients. Relationship with disease activity. Scand J Rheumatol 2002; 31: 205-10.DOI: 10.1080/030097402320318387 Taniguchi M, Nagaoka K, Kunikata T et al. Characterization of antihuman interleukin-18 (IL-18) interferon-gamma-inducing factor (IGIF) mononclonal antibodies and their application in the measurement of human IL-18 by ELISA. J Immunol Methods 1997; 206: 107-13.DOI: 10.1016/S0022-1759(97)00094-X Sayinalp N, Özcebe OI, Özdemir O et al. Cytokines in Behcet's disease. J Rheumatol 1996; 23: 321-2. Aeberli D, Oertle S, Mauron H et al. Inhibition of the TNF-pathway: use of infliximab and etanercept as remission-inducing agents in cases of therapy-resistant chronic inflammatory disorders. Swiss Med Wkly 2002; 32: 414-22. Gul A. Behcet's disease: an update on the pathogenesis. Clin Exp Rheumatol 2001; 19: S6-12. Turan B, Gallati H, Erdi H et al. Systemic levels of the T cell regulatory cytokines IL-10 and IL-12 in Behcet's disease; soluble TNFR-75 as a biological marker of disease activity. J Rheumatol 1997; 24: 128-32. Ahmad T, Wallace GR, James T et al. Mapping the HLA association in Behcet's disease: a role for tumour necrosis factor polymorphisms? Arthritis Rheum 2003; 48: 807-13.DOI: 10.1002/art.10815 Engelberts I, Moller A, Schoen GJ et al. Evaluation of measurement of human TNF in plasma by ELISA. Lymphokine Cytokine Res 1991; 10: 69-76. Kosar A, Haznedaroglu S, Karaaslan Y et al. Effects of interferon-alpha2a treatment on serum levels of tumour necrosis factor-alpha, tumour necrosis factor-alpha2 receptor, interleukin-2, interleukin-2 receptor, and E-selectin in Behcet's disease. Rheumatol Int 1999; 19: 11-4.DOI: 10.1007/s002960050091 1997; 206 1937; 105 1990; 335 2002; 31 1991; 10 1999; 19 1997; 386 1997; 24 2002; 32 2002; 11 2001; 19 2003; 48 1998; 177 1996; 23 b2_367 Gul A (b9_374) 2001; 19 Engelberts I (b7_372) 1991; 10 b11_376 Sayinalp N (b4_369) 1996; 23 Turan B (b13_378) 1997; 24 Behcet H (b1_366) 1937; 105 b5_370 b3_368 Aeberli D (b14_379) 2002; 32 b8_373 b12_377 Evans CA (b10_375) 1998; 177 b6_371
References_xml	– reference: Aeberli D, Oertle S, Mauron H et al. Inhibition of the TNF-pathway: use of infliximab and etanercept as remission-inducing agents in cases of therapy-resistant chronic inflammatory disorders. Swiss Med Wkly 2002; 32: 414-22. – reference: Taniguchi M, Nagaoka K, Kunikata T et al. Characterization of antihuman interleukin-18 (IL-18) interferon-gamma-inducing factor (IGIF) mononclonal antibodies and their application in the measurement of human IL-18 by ELISA. J Immunol Methods 1997; 206: 107-13.DOI: 10.1016/S0022-1759(97)00094-X – reference: Kosar A, Haznedaroglu S, Karaaslan Y et al. Effects of interferon-alpha2a treatment on serum levels of tumour necrosis factor-alpha, tumour necrosis factor-alpha2 receptor, interleukin-2, interleukin-2 receptor, and E-selectin in Behcet's disease. Rheumatol Int 1999; 19: 11-4.DOI: 10.1007/s002960050091 – reference: Ahmad T, Wallace GR, James T et al. Mapping the HLA association in Behcet's disease: a role for tumour necrosis factor polymorphisms? Arthritis Rheum 2003; 48: 807-13.DOI: 10.1002/art.10815 – reference: Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's disease. Lancet 1990; 335: 1078-80. – reference: Gul A. Behcet's disease: an update on the pathogenesis. Clin Exp Rheumatol 2001; 19: S6-12. – reference: Turan B, Gallati H, Erdi H et al. Systemic levels of the T cell regulatory cytokines IL-10 and IL-12 in Behcet's disease; soluble TNFR-75 as a biological marker of disease activity. J Rheumatol 1997; 24: 128-32. – reference: Hamzaoui K, Hamzaoui A, Guemira F et al. Cytokine profile in Behcet's disease patients. Relationship with disease activity. Scand J Rheumatol 2002; 31: 205-10.DOI: 10.1080/030097402320318387 – reference: Behcet H. Ueber rezidiverende aphtoese, durch ein virus verur sachte Geschwuere am mund am Auge und an den Genitalien. Dermatol Wochenschr 1937; 105: 1152. – reference: Engelberts I, Moller A, Schoen GJ et al. Evaluation of measurement of human TNF in plasma by ELISA. Lymphokine Cytokine Res 1991; 10: 69-76. – reference: Ghayur T, Banerjee S, Hugunin M et al. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 1997; 386: 619-23.DOI: 10.1038/386619a0 – reference: Evereklioglu C, Er H, Turkoz Y, Cekmen M. Serum levels of TNF-alpha, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behcet's disease. Med Inflamm 2002; 11: 87-93.DOI: 10.1080/09629350220131935 – reference: Sayinalp N, Özcebe OI, Özdemir O et al. Cytokines in Behcet's disease. J Rheumatol 1996; 23: 321-2. – reference: Evans CA, Jellis J, Hughes SP et al. Tumour necrosis factor-alpha, interleukin-6, and interleukin-8 secretion and the acute phase response in patients with bacterial and tuberculous osteomyelitis. J Infect Dis 1998; 177: 1582-7. – volume: 10 start-page: 69 year: 1991 end-page: 76 article-title: Evaluation of measurement of human TNF in plasma by ELISA publication-title: Lymphokine Cytokine Res – volume: 177 start-page: 1582 year: 1998 end-page: 7 article-title: Tumour necrosis factor‐alpha, interleukin‐6, and interleukin‐8 secretion and the acute phase response in patients with bacterial and tuberculous osteomyelitis publication-title: J Infect Dis – volume: 19 start-page: S6 year: 2001 end-page: 12 article-title: Behcet's disease: an update on the pathogenesis publication-title: Clin Exp Rheumatol – volume: 48 start-page: 807 year: 2003 end-page: 13 article-title: Mapping the HLA association in Behcet's disease: a role for tumour necrosis factor polymorphisms? publication-title: Arthritis Rheum – volume: 31 start-page: 205 year: 2002 end-page: 10 article-title: Cytokine profile in Behcet's disease patients. Relationship with disease activity publication-title: Scand J Rheumatol – volume: 23 start-page: 321 year: 1996 end-page: 2 article-title: Cytokines in Behcet's disease publication-title: J Rheumatol – volume: 32 start-page: 414 year: 2002 end-page: 22 article-title: Inhibition of the TNF‐pathway: use of infliximab and etanercept as remission‐inducing agents in cases of therapy‐resistant chronic inflammatory disorders publication-title: Swiss Med Wkly – volume: 206 start-page: 107 year: 1997 end-page: 13 article-title: Characterization of antihuman interleukin‐18 (IL‐18) interferon‐gamma‐inducing factor (IGIF) mononclonal antibodies and their application in the measurement of human IL‐18 by ELISA publication-title: J Immunol Methods – volume: 386 start-page: 619 year: 1997 end-page: 23 article-title: Caspase‐1 processes IFN‐gamma‐inducing factor and regulates LPS‐induced IFN‐gamma production publication-title: Nature – volume: 11 start-page: 87 year: 2002 end-page: 93 article-title: Serum levels of TNF‐alpha, sIL‐2R, IL‐6, and IL‐8 are increased and associated with elevated lipid peroxidation in patients with Behcet's disease publication-title: Med Inflamm – volume: 19 start-page: 11 year: 1999 end-page: 4 article-title: Effects of interferon‐alpha2a treatment on serum levels of tumour necrosis factor‐alpha, tumour necrosis factor‐alpha2 receptor, interleukin‐2, interleukin‐2 receptor, and E‐selectin in Behcet's disease publication-title: Rheumatol Int – volume: 24 start-page: 128 year: 1997 end-page: 32 article-title: Systemic levels of the T cell regulatory cytokines IL‐10 and IL‐12 in Behcet's disease; soluble TNFR‐75 as a biological marker of disease activity publication-title: J Rheumatol – volume: 335 start-page: 1078 year: 1990 end-page: 80 article-title: Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's disease publication-title: Lancet – volume: 105 start-page: 1152 year: 1937 article-title: Ueber rezidiverende aphtoese, durch ein virus verur sachte Geschwuere am mund am Auge und an den Genitalien publication-title: Dermatol Wochenschr – ident: b8_373 doi: 10.1080/09629350220131935 – ident: b12_377 doi: 10.1007/s002960050091 – ident: b11_376 doi: 10.1038/386619a0 – volume: 23 start-page: 321 year: 1996 ident: b4_369 publication-title: J Rheumatol – ident: b5_370 doi: 10.1016/0140-6736(90)92643-V – volume: 24 start-page: 128 year: 1997 ident: b13_378 publication-title: J Rheumatol – volume: 105 start-page: 1152 year: 1937 ident: b1_366 publication-title: Dermatol Wochenschr – ident: b3_368 doi: 10.1002/art.10815 – volume: 10 start-page: 69 year: 1991 ident: b7_372 publication-title: Lymphokine Cytokine Res – volume: 177 start-page: 1582 year: 1998 ident: b10_375 publication-title: J Infect Dis doi: 10.1086/515313 – ident: b6_371 doi: 10.1016/S0022-1759(97)00094-X – volume: 32 start-page: 414 year: 2002 ident: b14_379 publication-title: Swiss Med Wkly – volume: 19 start-page: S6 year: 2001 ident: b9_374 publication-title: Clin Exp Rheumatol – ident: b2_367 doi: 10.1080/030097402320318387
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Snippet	Summary Inflammation in Behcet's disease is thought to be mediated by cytokines derived from T‐helper type 1 (Th1) lymphocytes. In this study, we tried to... Inflammation in Behcet's disease is thought to be mediated by cytokines derived from T-helper type 1 (Th1) lymphocytes. In this study, we tried to determine...
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SubjectTerms	Adult Behcet Syndrome - blood Biological and medical sciences Enzyme-Linked Immunosorbent Assay Female Humans Interleukin-18 - blood Male Medical sciences Middle Aged Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Tumor Necrosis Factor-alpha - metabolism
Title	Serum interleukin 18 and tumour necrosis factor-α levels are increased in Behcet's disease
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