Decreased NURR1 and PITX3 gene expression in Chinese patients with Parkinson's disease

• Published in: European journal of neurology Vol. 19; no. 6; pp. 870 - 875
• Main Authors: Liu, H., Wei, L., Tao, Q., Deng, H., Ming, M., Xu, P., Le, W.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2012; John Wiley & Sons, Inc
• Subjects: Adult; Aged; Aged, 80 and over; Asian Continental Ancestry Group - genetics; Case-Control Studies; dopaminergic neurons; Female; Gene expression; Gene Expression Regulation - genetics; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Humans; Male; Middle Aged; Nuclear Receptor Subfamily 4, Group A, Member 2 - genetics; Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism; Panic attacks; Parkinson Disease - genetics; Parkinson's disease; peripheral blood lymphocytes; RNA, Messenger - metabolism; ROC Curve; transcription factor; Transcription Factors - genetics; Transcription Factors - metabolism; Young Adult

Background and purpose:  The preferential degeneration of midbrain dopaminergic (mDA) neurons in the substantia nigra pars compacta is the pathological hallmark in Parkinson’s disease (PD). The transcription factors NURR1 and PITX3 have been shown to play a crucial role in the maturation and surviva...