Interleukin‐1βconverting enzyme: A novel cysteine protease required for IL‐1β production and implicated in programmed cell death

• Published in: Protein science Vol. 4; no. 1; pp. 3 - 12
• Main Authors: Thornberry, Nancy A., Molineaux, Susan M.
• Format: Journal Article
• Language: English
• Published: Bristol Cold Spring Harbor Laboratory Press 01.01.1995
• Subjects: Amino Acid Sequence; apoptosis; Apoptosis - physiology; Caspase 1; Cysteine Endopeptidases - chemistry; Cysteine Endopeptidases - metabolism; cysteine protease; Cysteine Proteinase Inhibitors - pharmacology; Enzyme Activation; enzyme inhibition; inflammation; Interleukin-1 - metabolism; interleukin‐1; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Processing, Post-Translational; Substrate Specificity

Interleukin‐1β converting enzyme is the first member of a new class of cysteine proteases. The most distinguishing feature of this family is a nearly absolute specificity for cleavage at aspartic acid. This enzyme has been the subject of intense research because of its role in the production of IL‐1...