Alterations of the ocular surface epithelial mucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis

• Published in: Clinical and experimental allergy Vol. 36; no. 12; pp. 1556 - 1565
• Main Authors: Dogru, M., Okada, N., Asano-Kato, N., Igarashi, A., Fukagawa, K., Shimazaki, J., Tsubota, K., Fujishima, H.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2006; Blackwell
• Subjects: Adolescent; Adult; Allergic diseases; Analysis of Variance; atopy; Biological and medical sciences; brush cytology; Case-Control Studies; Child; Conjunctiva - chemistry; Conjunctiva - metabolism; Conjunctiva - pathology; conjunctival squamous metaplasia; corneal sensitivity; Dermatitis, Contact - immunology; Dermatitis, Contact - pathology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Expression; goblet cell; Goblet Cells - pathology; Humans; Immunohistochemistry; Immunopathology; impression cytology; Keratoconjunctivitis - immunology; Keratoconjunctivitis - pathology; Male; Medical sciences; Mucin-1 - analysis; Mucin-1 - genetics; Mucin-2; Mucin-4; Mucins - analysis; Mucins - genetics; Mucins - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - analysis; Statistics, Nonparametric; tear film; Tears - physiology; Tear film; Human; Immunopathology; Allergy; Cornea; impression cytology; Cytology; Keratopathy; Conjunctiva disease; Atopy; Squamous metaplasia; Visual system; Goblet cell; Eye disease; Keratoconjunctivitis; Sensitivity; Immunology; Mucin; brush cytology; corneal sensitivity; conjunctival squamous metaplasia; Anterior segment disease

Summary Background An increased understanding of the ocular surface alterations at the cellular level in the conjunctiva and the cornea, may help explain the pathogenesis and the subsequent clinical appearance of atopic ocular allergies, which may be potentially blinding. Purpose To investigate MUC...