A Novel Approach to Align Adult Neural Stem Cells on Micropatterned Conduits for Peripheral Nerve Regeneration: A Feasibility Study

• Published in: Artificial organs Vol. 33; no. 1; pp. 26 - 35
• Main Authors: Hsu, Shan-hui, Su, Chien-Hsiang, Chiu, Ing-Ming
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.01.2009
• Subjects: Adult Stem Cells - physiology; Animals; Cell alignment; Cell Proliferation; Cells, Cultured; Feasibility Studies; Gene Expression; l-lactide; Male; Mice; Micropattern; Nerve Regeneration; Neural stem cells; Poly(d; Poly(d,l‐lactide); Rats; Rats, Sprague-Dawley; Sciatic Neuropathy - therapy; Stem Cell Transplantation - methods; Tissue Engineering; Tissue Scaffolds

There is a strong need for nerve‐tissue engineering using the guide conduit and Schwann cells or neural stem cells (NSCs) with regeneration potential for injured peripheral nerves. In this study, micropatterned poly(d,l‐lactide) (PLA) conduits were fabricated by microlithography and solvent‐casting....