Apoptosis in rat jejunal mucosa is regulated partly through the central nervous system, which controls feeding behavior
Aim: The aim of this study was to investigate whether central nervous system‐related feeding behavior regulates mucosal apoptosis in rat small intestines. Methods: The test solutions used in this study were an H1 receptor antagonist (chlorpheniramine maleate), 2‐deoxy‐D‐glucose, leptin, and 1‐deox...
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| Published in | Journal of gastroenterology and hepatology Vol. 20; no. 8; pp. 1285 - 1291 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Melbourne, Australia
Blackwell Science Pty
01.08.2005
Blackwell Science |
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| Abstract | Aim: The aim of this study was to investigate whether central nervous system‐related feeding behavior regulates mucosal apoptosis in rat small intestines.
Methods: The test solutions used in this study were an H1 receptor antagonist (chlorpheniramine maleate), 2‐deoxy‐D‐glucose, leptin, and 1‐deoxy‐D‐glucosamine (2‐amino‐1,5‐anhydro‐2‐deoxy‐D‐glucitol). Test solutions were injected into the third cerebroventricles of rats. Feeding behavior and jejunal apoptosis were evaluated both with and without truncal vagotomy. Intestinal apoptosis was evaluated by percentage fragmented DNA, electrophoresis, and TUNEL staining.
Results: Chlorpheniramine and 2‐deoxy‐D‐glucose elicited feeding, whereas leptin and 1‐deoxy‐D‐glucosamine suppressed feeding. The test solutions, which elicited feeding (0.24 and 24 µmol/rat of chlorpheniramine and 2‐deoxy‐D‐glucose, respectively), suppressed mucosal apoptosis in the rat jejunum 1 h after cerebroventricular infusion. In contrast, the test solutions, which suppressed feeding (8 and 24 µmol/rat of leptin and 1‐deoxy‐D‐glucosamine, respectively), induced jejunal mucosal apoptosis 3 h after infusion. The effects of the test solutions on feeding behavior and changes in apoptosis were not affected by truncal vagotomy.
Conclusion: The central nervous system, which regulates feeding behavior, might control intestinal function through the regulation of intestinal apoptosis. |
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| AbstractList | Aim: The aim of this study was to investigate whether central nervous system‐related feeding behavior regulates mucosal apoptosis in rat small intestines.
Methods: The test solutions used in this study were an H1 receptor antagonist (chlorpheniramine maleate), 2‐deoxy‐D‐glucose, leptin, and 1‐deoxy‐D‐glucosamine (2‐amino‐1,5‐anhydro‐2‐deoxy‐D‐glucitol). Test solutions were injected into the third cerebroventricles of rats. Feeding behavior and jejunal apoptosis were evaluated both with and without truncal vagotomy. Intestinal apoptosis was evaluated by percentage fragmented DNA, electrophoresis, and TUNEL staining.
Results: Chlorpheniramine and 2‐deoxy‐D‐glucose elicited feeding, whereas leptin and 1‐deoxy‐D‐glucosamine suppressed feeding. The test solutions, which elicited feeding (0.24 and 24 µmol/rat of chlorpheniramine and 2‐deoxy‐D‐glucose, respectively), suppressed mucosal apoptosis in the rat jejunum 1 h after cerebroventricular infusion. In contrast, the test solutions, which suppressed feeding (8 and 24 µmol/rat of leptin and 1‐deoxy‐D‐glucosamine, respectively), induced jejunal mucosal apoptosis 3 h after infusion. The effects of the test solutions on feeding behavior and changes in apoptosis were not affected by truncal vagotomy.
Conclusion: The central nervous system, which regulates feeding behavior, might control intestinal function through the regulation of intestinal apoptosis. Abstract Aim: The aim of this study was to investigate whether central nervous system‐related feeding behavior regulates mucosal apoptosis in rat small intestines. Methods: The test solutions used in this study were an H 1 receptor antagonist (chlorpheniramine maleate), 2‐deoxy‐D‐glucose, leptin, and 1‐deoxy‐D‐glucosamine (2‐amino‐1,5‐anhydro‐2‐deoxy‐D‐glucitol). Test solutions were injected into the third cerebroventricles of rats. Feeding behavior and jejunal apoptosis were evaluated both with and without truncal vagotomy. Intestinal apoptosis was evaluated by percentage fragmented DNA, electrophoresis, and TUNEL staining. Results: Chlorpheniramine and 2‐deoxy‐D‐glucose elicited feeding, whereas leptin and 1‐deoxy‐D‐glucosamine suppressed feeding. The test solutions, which elicited feeding (0.24 and 24 µmol/rat of chlorpheniramine and 2‐deoxy‐D‐glucose, respectively), suppressed mucosal apoptosis in the rat jejunum 1 h after cerebroventricular infusion. In contrast, the test solutions, which suppressed feeding (8 and 24 µmol/rat of leptin and 1‐deoxy‐D‐glucosamine, respectively), induced jejunal mucosal apoptosis 3 h after infusion. The effects of the test solutions on feeding behavior and changes in apoptosis were not affected by truncal vagotomy. Conclusion: The central nervous system, which regulates feeding behavior, might control intestinal function through the regulation of intestinal apoptosis. The aim of this study was to investigate whether central nervous system-related feeding behavior regulates mucosal apoptosis in rat small intestines. The test solutions used in this study were an H(1) receptor antagonist (chlorpheniramine maleate), 2-deoxy-D-glucose, leptin, and 1-deoxy-D-glucosamine (2-amino-1,5-anhydro-2-deoxy-D-glucitol). Test solutions were injected into the third cerebroventricles of rats. Feeding behavior and jejunal apoptosis were evaluated both with and without truncal vagotomy. Intestinal apoptosis was evaluated by percentage fragmented DNA, electrophoresis, and TUNEL staining. Chlorpheniramine and 2-deoxy-D-glucose elicited feeding, whereas leptin and 1-deoxy-D-glucosamine suppressed feeding. The test solutions, which elicited feeding (0.24 and 24 micromol/rat of chlorpheniramine and 2-deoxy-D-glucose, respectively), suppressed mucosal apoptosis in the rat jejunum 1 h after cerebroventricular infusion. In contrast, the test solutions, which suppressed feeding (8 and 24 micromol/rat of leptin and 1-deoxy-D-glucosamine, respectively), induced jejunal mucosal apoptosis 3 h after infusion. The effects of the test solutions on feeding behavior and changes in apoptosis were not affected by truncal vagotomy. The central nervous system, which regulates feeding behavior, might control intestinal function through the regulation of intestinal apoptosis. AIMThe aim of this study was to investigate whether central nervous system-related feeding behavior regulates mucosal apoptosis in rat small intestines.METHODSThe test solutions used in this study were an H(1) receptor antagonist (chlorpheniramine maleate), 2-deoxy-D-glucose, leptin, and 1-deoxy-D-glucosamine (2-amino-1,5-anhydro-2-deoxy-D-glucitol). Test solutions were injected into the third cerebroventricles of rats. Feeding behavior and jejunal apoptosis were evaluated both with and without truncal vagotomy. Intestinal apoptosis was evaluated by percentage fragmented DNA, electrophoresis, and TUNEL staining.RESULTSChlorpheniramine and 2-deoxy-D-glucose elicited feeding, whereas leptin and 1-deoxy-D-glucosamine suppressed feeding. The test solutions, which elicited feeding (0.24 and 24 micromol/rat of chlorpheniramine and 2-deoxy-D-glucose, respectively), suppressed mucosal apoptosis in the rat jejunum 1 h after cerebroventricular infusion. In contrast, the test solutions, which suppressed feeding (8 and 24 micromol/rat of leptin and 1-deoxy-D-glucosamine, respectively), induced jejunal mucosal apoptosis 3 h after infusion. The effects of the test solutions on feeding behavior and changes in apoptosis were not affected by truncal vagotomy.CONCLUSIONThe central nervous system, which regulates feeding behavior, might control intestinal function through the regulation of intestinal apoptosis. |
| Author | OOTANI, AKIFUMI FUJIMOTO, KAZUMA LIN, TAISAN DANJO, AKIKO IWAKIRI, RYUICHI AMEMORI, SADAHIRO TSUNADA, SEIJI SAKATA, YASUHISA YOKOYAMA, FUMIE FUJISE, TAKEHIRO SAKATA, HIROYUKI TODA, SHUJI |
| Author_xml | – sequence: 1 givenname: TAISAN surname: LIN fullname: LIN, TAISAN organization: Departments of Internal Medicine – sequence: 2 givenname: HIROYUKI surname: SAKATA fullname: SAKATA, HIROYUKI organization: Departments of Internal Medicine – sequence: 3 givenname: AKIFUMI surname: OOTANI fullname: OOTANI, AKIFUMI organization: Departments of Internal Medicine – sequence: 4 givenname: TAKEHIRO surname: FUJISE fullname: FUJISE, TAKEHIRO organization: Departments of Internal Medicine – sequence: 5 givenname: SEIJI surname: TSUNADA fullname: TSUNADA, SEIJI organization: Departments of Internal Medicine – sequence: 6 givenname: SADAHIRO surname: AMEMORI fullname: AMEMORI, SADAHIRO organization: Departments of Internal Medicine – sequence: 7 givenname: AKIKO surname: DANJO fullname: DANJO, AKIKO organization: Departments of Internal Medicine – sequence: 8 givenname: FUMIE surname: YOKOYAMA fullname: YOKOYAMA, FUMIE organization: Departments of Internal Medicine – sequence: 9 givenname: YASUHISA surname: SAKATA fullname: SAKATA, YASUHISA organization: Departments of Internal Medicine – sequence: 10 givenname: RYUICHI surname: IWAKIRI fullname: IWAKIRI, RYUICHI organization: Departments of Internal Medicine – sequence: 11 givenname: SHUJI surname: TODA fullname: TODA, SHUJI organization: Pathology, Saga Medical School, Nabeshima, Saga, Japan – sequence: 12 givenname: KAZUMA surname: FUJIMOTO fullname: FUJIMOTO, KAZUMA email: fujimoto@med.saga-u.ac.jp organization: Departments of Internal Medicine |
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| Keywords | Brain Trunk Glucosamine Rat Mucosa percentage fragmented DNA Central nervous system Check Hypothalamus brain gut axis Antihistaminic Small intestine Encephalon Prevention Regulation(control) Jejunum Electrophoresis Antagonist Antirheumatic agent Chlorphenamine Feeding behavior vagal nerve Rodentia Gut feeding center Feeding Vertebrata Mammalia Animal DNA H1 Histamine receptor Apoptosis |
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| Snippet | Aim: The aim of this study was to investigate whether central nervous system‐related feeding behavior regulates mucosal apoptosis in rat small intestines.... The aim of this study was to investigate whether central nervous system-related feeding behavior regulates mucosal apoptosis in rat small intestines. The test... Abstract Aim: The aim of this study was to investigate whether central nervous system‐related feeding behavior regulates mucosal apoptosis in rat small... AIMThe aim of this study was to investigate whether central nervous system-related feeding behavior regulates mucosal apoptosis in rat small... |
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| SubjectTerms | Animals Apoptosis - physiology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Brain Chemistry brain gut axis Central Nervous System - drug effects Central Nervous System - physiology Chlorpheniramine - administration & dosage Chlorpheniramine - pharmacology Deoxyglucose - administration & dosage Deoxyglucose - pharmacology Feeding Behavior - drug effects Feeding Behavior - physiology feeding center Histamine H1 Antagonists - administration & dosage Histamine H1 Antagonists - pharmacology hypothalamus Hypothalamus - physiology Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Intestinal Mucosa - innervation Jejunum - drug effects Jejunum - innervation Jejunum - metabolism Leptin - pharmacology Male Medical sciences percentage fragmented DNA Pharmacology. Drug treatments Rats Rats, Sprague-Dawley vagal nerve Vagotomy |
| Title | Apoptosis in rat jejunal mucosa is regulated partly through the central nervous system, which controls feeding behavior |
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