Increased levels of SNAP-25 and synaptophysin in the dorsolateral prefrontal cortex in bipolar I disorder

• Published in: Bipolar disorders Vol. 8; no. 2; pp. 133 - 143
• Main Authors: Scarr, E, Gray, L, Keriakous, D, Robinson, PJ, Dean, B
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2006
• Subjects: alpha-Synuclein - immunology; alpha-Synuclein - metabolism; Antibodies; Bipolar Disorder - immunology; Bipolar Disorder - metabolism; Cell Adhesion Molecules - immunology; Cell Adhesion Molecules - metabolism; Cell Culture Techniques; Dynamin I - immunology; Dynamin I - metabolism; Female; human; Humans; Male; mental disorders; Middle Aged; Polymerase Chain Reaction; postmortem; Prefrontal Cortex - anatomy & histology; Prefrontal Cortex - metabolism; Prefrontal Cortex - pathology; Qa-SNARE Proteins - immunology; Qa-SNARE Proteins - metabolism; R-SNARE Proteins - immunology; R-SNARE Proteins - metabolism; RNA, Messenger - immunology; RNA, Messenger - metabolism; Schizophrenia - immunology; Schizophrenia - metabolism; synaptophysin; Synaptophysin - metabolism; Synaptosomal-Associated Protein 25 - metabolism; synaptosomal-associated protein-25

Objective:  In order to identify whether the mechanisms associated with neurotransmitter release are involved in the pathologies of bipolar disorder and schizophrenia, levels of presynaptic [synaptosomal‐associated protein‐25 (SNAP‐25), syntaxin, synaptophysin, vesicle‐associated membrane protein, d...