Omega‐3 Polyunsaturated Fatty Acids Inhibit IL‐17A Secretion through Decreased ICAM‐1 Expression in T Cells Co‐Cultured with Adipose‐Derived Stem Cells Harvested from Adipose Tissues of Obese Subjects

• Published in: Molecular nutrition & food research Vol. 63; no. 11; pp. e1801148 - n/a
• Main Authors: Chehimi, Marwa, Ward, Robert, Pestel, Julien, Robert, Maud, Pesenti, Sandra, Bendridi, Nadia, Michalski, Marie‐Caroline, Laville, Martine, Vidal, Hubert, Eljaafari, Assia
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.06.2019
• Subjects: Adipocytes; Adipose tissue; Adipose Tissue - cytology; adipose tissue‐derived stem cells; alpha-linolenic acid; alpha-Linolenic Acid - pharmacology; Cell Aggregation - drug effects; coculture; Coculture Techniques; Docosahexaenoic acid; eicosapentaenoic acid; Fatty acids; Fatty Acids, Omega-3 - pharmacology; Helper cells; Humans; ICAM‐1; IL‐17A; Immune system; Inflammation; intercellular adhesion molecule-1; Intercellular Adhesion Molecule-1 - genetics; interleukin-17; Interleukin-17 - antagonists & inhibitors; Interleukin-17 - biosynthesis; interleukin-1beta; interleukin-6; Leukocytes (mononuclear); Linolenic acid; Lymphocytes T; Monocytes; obese adipose tissues; Obesity - metabolism; Omega 3 PUFA; omega-3 fatty acids; Oxygenase; Palmitic acid; Polyunsaturated fatty acids; secretion; STAT3 Transcription Factor - antagonists & inhibitors; Stem cells; Stem Cells - drug effects; Stem Cells - immunology; Stem Cells - physiology; T-lymphocytes; Th17 Cells - drug effects; Th17 Cells - immunology; Toll-like receptor 4; Toll-Like Receptor 4 - antagonists & inhibitors; Toll-like receptors; Transcription; tumor necrosis factor-alpha; Tumor necrosis factor-α; Omega 3 PUFA; obese adipose tissues; ICAM-1; IL-17A; adipose tissue-derived stem cells

Scope Obese adipose tissue (AT) is infiltrated by inflammatory immune cells including IL‐17A‐producing‐T (Th17) cells. It has been previously demonstrated that adipose‐derived stem cells from obese (ob‐ASCs), but not lean AT promote Th17 cells. Because n‐3 PUFAs are known to inhibit obese AT inflamm...