In vivo synaptic density relates to glucose metabolism at rest in healthy subjects, but is strongly modulated by regional differences

• Published in: Journal of cerebral blood flow and metabolism Vol. 41; no. 8; pp. 1978 - 1987
• Main Authors: van Aalst, June, Ceccarini, Jenny, Sunaert, Stefan, Dupont, Patrick, Koole, Michel, Van Laere, Koen
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.08.2021
• Subjects: Adult; Brain - diagnostic imaging; Brain - metabolism; Energy Metabolism; Female; Fluorodeoxyglucose F18 - chemistry; Glucose - metabolism; Healthy Volunteers; Humans; Image Processing, Computer-Assisted; Membrane Glycoproteins - metabolism; Microglia - metabolism; Nerve Tissue Proteins - metabolism; Original; Positron-Emission Tomography; Pyrrolidinones - chemistry; Synapses - physiology; Young Adult; PET-MR imaging; synaptic density; Glucose metabolism; [18F]FDG; [11C]UCB-J

Preclinical and postmortem studies have suggested that regional synaptic density and glucose consumption (CMRGlc) are strongly related. However, the relation between synaptic density and cerebral glucose metabolism in the human brain has not directly been assessed in vivo. Using [11C]UCB-J binding t...