Short-term interval training alters brain glucose metabolism in subjects with insulin resistance

• Published in: Journal of cerebral blood flow and metabolism Vol. 38; no. 10; pp. 1828 - 1838
• Main Authors: Honkala, Sanna M, Johansson, Jarkko, Motiani, Kumail K, Eskelinen, Jari-Joonas, Virtanen, Kirsi A, Löyttyniemi, Eliisa, Knuuti, Juhani, Nuutila, Pirjo, Kalliokoski, Kari K, Hannukainen, Jarna C
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.10.2018
• Subjects: Adult; Brain - metabolism; Energy Metabolism; Female; Glucose - metabolism; High-Intensity Interval Training; Humans; Insulin Resistance - physiology; Lipid Metabolism - physiology; Male; Middle Aged; Original; Physical Conditioning, Human - methods; Physical Conditioning, Human - physiology; brain glucose metabolism; Insulin resistance; positron emission tomography; exercise training; brain lipid metabolism

Brain insulin-stimulated glucose uptake (GU) is increased in obese and insulin resistant subjects but normalizes after weight loss along with improved whole-body insulin sensitivity. Our aim was to study whether short-term exercise training (moderate intensity continuous training (MICT) or sprint in...