Pharmacokinetic study of valproic acid sustained-release preparation in patients undergoing brain surgery

• Published in: Therapeutic drug monitoring Vol. 17; no. 1; p. 6
• Main Authors: Ieiri, I, Morioka, T, Ichimiya, T, Nishio, S, Fukui, M, Ohtsubo, K, Higuchi, S
• Format: Journal Article
• Language: English
• Published: United States 01.02.1995
• Subjects: Adolescent; Adult; Aged; Brain - surgery; Delayed-Action Preparations; Female; Humans; Intraoperative Period; Male; Middle Aged; Postoperative Period; Serum Albumin - metabolism; Valproic Acid - administration & dosage; Valproic Acid - pharmacokinetics

Pharmacokinetics of valproic acid sustained-release preparation (VPA-SR) were studied in nine patients undergoing surgery for brain tumor. Total (t) and free (f) serum concentrations were analyzed in samples drawn during the day of brain surgery and compared with levels from a postoperative day. The...