Interaction of human keratinocytes and nerve fiber terminals at the neuro-cutaneous unit

• Published in: eLife Vol. 13
• Main Authors: Erbacher, Christoph, Britz, Sebastian, Dinkel, Philine, Klein, Thomas, Sauer, Markus, Stigloher, Christian, Üçeyler, Nurcan
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 16.01.2024; eLife Sciences Publications, Ltd
• Subjects: Animal models; Animals; Axons; Cell culture; Connexin 43; Epidermis; External stimuli; Humans; keratinocyte; Keratinocytes; Keratinocytes - physiology; Labeling; Microscopy; Nerve Fibers; neuro-cutaneous unit; neuropathic pain; Neuropathy; Neuroscience; Pain perception; Pathology; Peripheral neuropathy; Proteins; Scanning electron microscopy; Sensory neurons; Signal transduction; Skin; Skin - innervation; super-resolution microscopy; Tomography; neuropathic pain; keratinocyte; neuroscience; sensory neurons; neuro-cutaneous unit; human; super-resolution microscopy

Traditionally, peripheral sensory neurons are assumed as the exclusive transducers of external stimuli. Current research moves epidermal keratinocytes into focus as sensors and transmitters of nociceptive and non-nociceptive sensations, tightly interacting with intraepidermal nerve fibers at the neu...