Gallic acid and omega-3 fatty acids decrease inflammatory and oxidative stress in manganese-treated rats

• Published in: Experimental biology and medicine (Maywood, N.J.) Vol. 245; no. 9; pp. 835 - 844
• Main Authors: Owumi, Solomon E, Nwozo, Sarah O, Effiong, Magdalene E, Najophe, Eseroghene S
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.05.2020
• Subjects: Animals; Chemical and Drug Induced Liver Injury - pathology; Fatty Acids, Omega-3 - pharmacology; Gallic Acid - pharmacology; Inflammation - chemically induced; Inflammation - pathology; Kidney Diseases - chemically induced; Kidney Diseases - pathology; Male; Manganese - toxicity; Original Research; Oxidative Stress - drug effects; Random Allocation; Rats; Rats, Wistar; omega-3 fatty acids; rats; hepatorenal toxicity; gallic acid; oxido-inflammation; Manganese

Evidence abounds—epidemiological and experimental—linking overexposure to manganese with hepatic and renal dysfunction. We investigated the beneficial effects of gallic acid or omega-3 fatty acids (ω-3-FA) on hepatorenal function in rats exposed to manganese (Mn). Rats were exposed to manganese (15 ...