Noninvasive optical monitoring of critical closing pressure and arteriole compliance in human subjects

• Published in: Journal of cerebral blood flow and metabolism Vol. 37; no. 8; pp. 2691 - 2705
• Main Authors: Baker, Wesley B, Parthasarathy, Ashwin B, Gannon, Kimberly P, Kavuri, Venkaiah C, Busch, David R, Abramson, Kenneth, He, Lian, Mesquita, Rickson C, Mullen, Michael T, Detre, John A, Greenberg, Joel H, Licht, Daniel J, Balu, Ramani, Kofke, W Andrew, Yodh, Arjun G
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.08.2017
• Subjects: Adult; Blood Flow Velocity - physiology; Blood Pressure - physiology; Cerebrovascular Circulation - physiology; Craniocerebral Trauma - diagnostic imaging; Craniocerebral Trauma - physiopathology; Healthy Volunteers; Humans; Intracranial Pressure - physiology; Microvessels - diagnostic imaging; Microvessels - physiopathology; Models, Biological; Monitoring, Physiologic - instrumentation; Monitoring, Physiologic - methods; Optical Imaging; Rapid Communications; Sensitivity and Specificity; Spectrum Analysis; Ultrasonography, Doppler, Transcranial; near infrared spectroscopy; Arterioles; cerebral blood flow measurement; intrinsic optical imaging; neurocritical care

The critical closing pressure (CrCP) of the cerebral circulation depends on both tissue intracranial pressure and vasomotor tone. CrCP defines the arterial blood pressure (ABP) at which cerebral blood flow approaches zero, and their difference (ABP − CrCP) is an accurate estimate of cerebral perfusi...