Characterization of a novel thogotovirus isolated from Amblyomma testudinarium ticks in Ehime, Japan: A significant phylogenetic relationship to Bourbon virus
•A new thogotovirus was isolated from Amblyomma testudinarium ticks in Japan.•Oz virus (OZV) was genetically and biologically characterized.•OZV is closely related to Bourbon virus, a human-pathogenic thogotovirus in the US. The genus Thogotovirus, as represented by Thogoto virus and Dhori virus, co...
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| Published in | Virus research Vol. 249; pp. 57 - 65 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Netherlands
Elsevier B.V
02.04.2018
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| Abstract | •A new thogotovirus was isolated from Amblyomma testudinarium ticks in Japan.•Oz virus (OZV) was genetically and biologically characterized.•OZV is closely related to Bourbon virus, a human-pathogenic thogotovirus in the US.
The genus Thogotovirus, as represented by Thogoto virus and Dhori virus, comprises a group of arthropod-borne viruses, most members of which are transmitted by ticks. Here we report the genetic and biological characterization of a new thogotovirus, designated Oz virus (OZV), isolated from the hard tick Amblyomma testudinarium in Ehime, Japan. OZV efficiently replicated and induced a cytopathic effect in Vero cells, from which enveloped pleomorphic virus particles were formed by budding. OZV could also replicate in BHK-21 and DH82 cells and caused high mortality in suckling mice after intracerebral inoculation. Phylogenetic analyses of six viral proteins indicated that OZV is clustered with Dhori and related viruses, and is most closely related in glycoprotein (GP) and matrix protein (M) sequences to Bourbon virus, a human-pathogenic thogotovirus discovered recently in the United States. Our findings emphasize the need for understanding the geographic distribution and ecology of OZV and related viruses and for reevaluation of the medical and public health importance of thogotoviruses. |
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| AbstractList | •A new thogotovirus was isolated from Amblyomma testudinarium ticks in Japan.•Oz virus (OZV) was genetically and biologically characterized.•OZV is closely related to Bourbon virus, a human-pathogenic thogotovirus in the US.
The genus Thogotovirus, as represented by Thogoto virus and Dhori virus, comprises a group of arthropod-borne viruses, most members of which are transmitted by ticks. Here we report the genetic and biological characterization of a new thogotovirus, designated Oz virus (OZV), isolated from the hard tick Amblyomma testudinarium in Ehime, Japan. OZV efficiently replicated and induced a cytopathic effect in Vero cells, from which enveloped pleomorphic virus particles were formed by budding. OZV could also replicate in BHK-21 and DH82 cells and caused high mortality in suckling mice after intracerebral inoculation. Phylogenetic analyses of six viral proteins indicated that OZV is clustered with Dhori and related viruses, and is most closely related in glycoprotein (GP) and matrix protein (M) sequences to Bourbon virus, a human-pathogenic thogotovirus discovered recently in the United States. Our findings emphasize the need for understanding the geographic distribution and ecology of OZV and related viruses and for reevaluation of the medical and public health importance of thogotoviruses. The genus Thogotovirus, as represented by Thogoto virus and Dhori virus, comprises a group of arthropod-borne viruses, most members of which are transmitted by ticks. Here we report the genetic and biological characterization of a new thogotovirus, designated Oz virus (OZV), isolated from the hard tick Amblyomma testudinarium in Ehime, Japan. OZV efficiently replicated and induced a cytopathic effect in Vero cells, from which enveloped pleomorphic virus particles were formed by budding. OZV could also replicate in BHK-21 and DH82 cells and caused high mortality in suckling mice after intracerebral inoculation. Phylogenetic analyses of six viral proteins indicated that OZV is clustered with Dhori and related viruses, and is most closely related in glycoprotein (GP) and matrix protein (M) sequences to Bourbon virus, a human-pathogenic thogotovirus discovered recently in the United States. Our findings emphasize the need for understanding the geographic distribution and ecology of OZV and related viruses and for reevaluation of the medical and public health importance of thogotoviruses.The genus Thogotovirus, as represented by Thogoto virus and Dhori virus, comprises a group of arthropod-borne viruses, most members of which are transmitted by ticks. Here we report the genetic and biological characterization of a new thogotovirus, designated Oz virus (OZV), isolated from the hard tick Amblyomma testudinarium in Ehime, Japan. OZV efficiently replicated and induced a cytopathic effect in Vero cells, from which enveloped pleomorphic virus particles were formed by budding. OZV could also replicate in BHK-21 and DH82 cells and caused high mortality in suckling mice after intracerebral inoculation. Phylogenetic analyses of six viral proteins indicated that OZV is clustered with Dhori and related viruses, and is most closely related in glycoprotein (GP) and matrix protein (M) sequences to Bourbon virus, a human-pathogenic thogotovirus discovered recently in the United States. Our findings emphasize the need for understanding the geographic distribution and ecology of OZV and related viruses and for reevaluation of the medical and public health importance of thogotoviruses. The genus Thogotovirus, as represented by Thogoto virus and Dhori virus, comprises a group of arthropod-borne viruses, most members of which are transmitted by ticks. Here we report the genetic and biological characterization of a new thogotovirus, designated Oz virus (OZV), isolated from the hard tick Amblyomma testudinarium in Ehime, Japan. OZV efficiently replicated and induced a cytopathic effect in Vero cells, from which enveloped pleomorphic virus particles were formed by budding. OZV could also replicate in BHK-21 and DH82 cells and caused high mortality in suckling mice after intracerebral inoculation. Phylogenetic analyses of six viral proteins indicated that OZV is clustered with Dhori and related viruses, and is most closely related in glycoprotein (GP) and matrix protein (M) sequences to Bourbon virus, a human-pathogenic thogotovirus discovered recently in the United States. Our findings emphasize the need for understanding the geographic distribution and ecology of OZV and related viruses and for reevaluation of the medical and public health importance of thogotoviruses. |
| Author | Minami, Shohei Sato, Tomomi Saijo, Masayuki Hattori, Masashi Mizutani, Tetsuya Isawa, Haruhiko Kobayashi, Daisuke Horiya, Madoka Kuwata, Ryusei Sawabe, Kyoko Takayama-Ito, Mutsuyo Kan, Miki Posadas-Herrera, Guillermo Lim, Chang-Kweng Kimura, Toshiya Murota, Katsunori Kaku, Koki Katayama, Yukie Ejiri, Hiroko Fujita, Ryosuke Yamaguchi, Yukie Shinomiya, Hiroto Maeda, Ken Shimoda, Hiroshi |
| Author_xml | – sequence: 1 givenname: Hiroko surname: Ejiri fullname: Ejiri, Hiroko organization: Department of Medical Entomology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan – sequence: 2 givenname: Chang-Kweng surname: Lim fullname: Lim, Chang-Kweng organization: Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan – sequence: 3 givenname: Haruhiko surname: Isawa fullname: Isawa, Haruhiko email: hisawa@nih.go.jp organization: Department of Medical Entomology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan – sequence: 4 givenname: Ryosuke orcidid: 0000-0002-0098-8878 surname: Fujita fullname: Fujita, Ryosuke organization: Department of Medical Entomology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan – sequence: 5 givenname: Katsunori surname: Murota fullname: Murota, Katsunori organization: Department of Medical Entomology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan – sequence: 6 givenname: Tomomi surname: Sato fullname: Sato, Tomomi organization: Department of Medical Entomology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan – sequence: 7 givenname: Daisuke surname: Kobayashi fullname: Kobayashi, Daisuke organization: Department of Medical Entomology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan – sequence: 8 givenname: Miki surname: Kan fullname: Kan, Miki organization: Ehime Prefectural Institute of Public Health and Environmental Science, 8-234 Sanban-cho, Matsuyama, Ehime 790-0003, Japan – sequence: 9 givenname: Masashi surname: Hattori fullname: Hattori, Masashi organization: Ehime Prefectural Institute of Public Health and Environmental Science, 8-234 Sanban-cho, Matsuyama, Ehime 790-0003, Japan – sequence: 10 givenname: Toshiya surname: Kimura fullname: Kimura, Toshiya organization: Ehime Prefectural Institute of Public Health and Environmental Science, 8-234 Sanban-cho, Matsuyama, Ehime 790-0003, Japan – sequence: 11 givenname: Yukie surname: Yamaguchi fullname: Yamaguchi, Yukie organization: Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan – sequence: 12 givenname: Mutsuyo orcidid: 0000-0002-3805-4165 surname: Takayama-Ito fullname: Takayama-Ito, Mutsuyo organization: Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan – sequence: 13 givenname: Madoka surname: Horiya fullname: Horiya, Madoka organization: Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan – sequence: 14 givenname: Guillermo orcidid: 0000-0003-1622-8571 surname: Posadas-Herrera fullname: Posadas-Herrera, Guillermo organization: Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan – sequence: 15 givenname: Shohei surname: Minami fullname: Minami, Shohei organization: Laboratory of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan – sequence: 16 givenname: Ryusei surname: Kuwata fullname: Kuwata, Ryusei organization: Laboratory of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan – sequence: 17 givenname: Hiroshi surname: Shimoda fullname: Shimoda, Hiroshi organization: Laboratory of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan – sequence: 18 givenname: Ken surname: Maeda fullname: Maeda, Ken organization: Laboratory of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan – sequence: 19 givenname: Yukie surname: Katayama fullname: Katayama, Yukie organization: Research and Education Center for Prevention of Global Infectious Disease of Animal, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan – sequence: 20 givenname: Tetsuya surname: Mizutani fullname: Mizutani, Tetsuya organization: Research and Education Center for Prevention of Global Infectious Disease of Animal, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan – sequence: 21 givenname: Masayuki orcidid: 0000-0001-5458-7298 surname: Saijo fullname: Saijo, Masayuki organization: Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan – sequence: 22 givenname: Koki surname: Kaku fullname: Kaku, Koki organization: Division of infectious Diseases Epidemiology and Control, National Defense Medical Research Institute, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan – sequence: 23 givenname: Hiroto surname: Shinomiya fullname: Shinomiya, Hiroto organization: Ehime Prefectural Institute of Public Health and Environmental Science, 8-234 Sanban-cho, Matsuyama, Ehime 790-0003, Japan – sequence: 24 givenname: Kyoko surname: Sawabe fullname: Sawabe, Kyoko email: sawabe@nih.go.jp organization: Department of Medical Entomology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29548745$$D View this record in MEDLINE/PubMed |
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| Copyright | 2018 Elsevier B.V. Copyright © 2018 Elsevier B.V. All rights reserved. |
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| Keywords | Amblyomma testudinarium Thogotovirus Whole-genome analysis Tick-borne virus |
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| Snippet | •A new thogotovirus was isolated from Amblyomma testudinarium ticks in Japan.•Oz virus (OZV) was genetically and biologically characterized.•OZV is closely... The genus Thogotovirus, as represented by Thogoto virus and Dhori virus, comprises a group of arthropod-borne viruses, most members of which are transmitted by... |
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| SubjectTerms | Amblyomma testudinarium Thogotovirus Tick-borne virus Whole-genome analysis |
| Title | Characterization of a novel thogotovirus isolated from Amblyomma testudinarium ticks in Ehime, Japan: A significant phylogenetic relationship to Bourbon virus |
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