Hydroxyurea therapy modulates sickle cell anemia red blood cell physiology: Impact on RBC deformability, oxidative stress, nitrite levels and nitric oxide synthase signalling pathway

• Published in: Nitric oxide Vol. 81; pp. 28 - 35
• Main Authors: Nader, Elie, Grau, Marijke, Fort, Romain, Collins, Bianca, Cannas, Giovanna, Gauthier, Alexandra, Walpurgis, Katja, Martin, Cyril, Bloch, Wilhelm, Poutrel, Solène, Hot, Arnaud, Renoux, Céline, Thevis, Mario, Joly, Philippe, Romana, Marc, Guillot, Nicolas, Connes, Philippe
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2018; Elsevier
• Subjects: Adult; Anemia, Sickle Cell - drug therapy; Deformability; Erythrocyte Deformability - drug effects; Erythrocytes - drug effects; Erythrocytes - physiology; Female; Hematology; Human health and pathology; Humans; Hydroxyurea; Hydroxyurea - pharmacology; Life Sciences; Male; Nitric oxide; Nitric Oxide - blood; Nitric Oxide Synthase - metabolism; Nitrites - blood; Nitroprusside - pharmacology; Oxidative stress; Oxidative Stress - drug effects; Phosphorylation - drug effects; Proto-Oncogene Proteins c-akt - metabolism; Reactive Oxygen Species - blood; Sickle cell anaemia; Signal Transduction - drug effects; Oxidative stress; Hydroxyurea; Deformability; Sickle cell anaemia; Nitric oxide

Hydroxyurea (HU) has been suggested to act as a nitric oxide (NO) donor in sickle cell anemia (SCA). However, little is known about the HU NO-related effects on red blood cell (RBC) physiology and NO signalling pathway. Thirty-four patients with SCA (22 under HU treatment (HU+) and 12 without (HU-))...