Differential use of p24 family members as cargo receptors for the transport of glycosylphosphatidylinositol-anchored proteins and Wnt1

• Published in: Journal of biochemistry (Tokyo) Vol. 171; no. 1; pp. 75 - 83
• Main Authors: Tashima, Yuko, Hirata, Tetsuya, Maeda, Yusuke, Murakami, Yoshiko, Kinoshita, Taroh
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2022
• Subjects: Animals; Carrier Proteins - metabolism; Endoplasmic Reticulum - metabolism; Glycosylphosphatidylinositols - metabolism; Golgi Apparatus - metabolism; Protein Transport; p24 complex; transport; GPI-anchored proteins; Wnt1; subunit composition

Abstract Complexes of p24 proteins act as cargo receptors for the transport of COPII vesicles from the endoplasmic reticulum (ER). The major cargos of p24 complexes are hydrophilic proteins tethered to the ER membrane via a covalently attached glycosylphosphatidylinositol (GPI) or fatty acid. Each p...