Zoonotic origins of human coronaviruses

• Published in: International journal of biological sciences Vol. 16; no. 10; pp. 1686 - 1697
• Main Authors: Ye, Zi-Wei, Yuan, Shuofeng, Yuen, Kit-San, Fung, Sin-Yee, Chan, Chi-Ping, Jin, Dong-Yan
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2020; Ivyspring International Publisher
• Subjects: Animals; Betacoronavirus - isolation & purification; Biological evolution; China; Chiroptera - virology; Coevolution; Common cold; Coronaviridae; Coronavirus - classification; Coronavirus - isolation & purification; Coronavirus Infections; Coronaviruses; COVID-19; Disease Reservoirs - veterinary; Disease Reservoirs - virology; Disease transmission; Epidemics; Evolution; Evolution, Molecular; Genomes; Host alternation; Host-Pathogen Interactions; Humans; Middle East respiratory syndrome; Mutation; Origins; Pandemics; Pathogenesis; Pathogenicity; Pathogens; Pneumonia, Viral; Recombination; Respiratory diseases; Review; Rodentia - virology; SARS Virus; SARS-CoV-2; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome coronavirus 2; Switches; Viral diseases; Viruses; Zoonoses; Zoonoses - transmission; Zoonoses - virology; China; Middle East; Netherlands; COVID-19; animal reservoir; bats; SARS-CoV-2; SARS-CoV; coronavirus; MERS-CoV

Mutation and adaptation have driven the co-evolution of coronaviruses (CoVs) and their hosts, including human beings, for thousands of years. Before 2003, two human CoVs (HCoVs) were known to cause mild illness, such as common cold. The outbreaks of severe acute respiratory syndrome (SARS) and the M...