Recipient-Based Approach to Tailoring Immunosuppression in Liver Transplantation

Abstract Improvements in the field of transplant immunosuppression (IS) have led to significant advances in long-term survival of liver transplant recipients. Despite this progress, survival rates vary depending on recipient, donor and/or perioperative factors. Tailoring IS based on recipient factor...

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Bibliographic Details
Published inTransplantation proceedings Vol. 42; no. 5; pp. 1731 - 1737
Main Authors Kemmer, N, Neff, G
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2010
Subjects
Aged
Carcinoma, Hepatocellular - surgery
Cholestasis - surgery
Cytochrome P-450 CYP3A - genetics
Ethnic Groups
Genetic Variation
Genome, Human
HIV Infections - complications
Humans
Immunosuppression - methods
Immunosuppressive Agents - classification
Immunosuppressive Agents - therapeutic use
Liver Diseases - classification
Liver Diseases - surgery
Liver Neoplasms - surgery
Liver Transplantation - immunology
Liver Transplantation - mortality
Patients - classification
Patients - psychology
Pharmacogenetics
Physician-Patient Relations
Surgery
Treatment Outcome
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Summary:Abstract Improvements in the field of transplant immunosuppression (IS) have led to significant advances in long-term survival of liver transplant recipients. Despite this progress, survival rates vary depending on recipient, donor and/or perioperative factors. Tailoring IS based on recipient factors is of growing interest among health care providers involved in the care of organ transplant recipients. To date there is no consensus document addressing individualized IS therapy for liver transplant recipients. This review will discuss the information available on the effect of the various IS drugs on recipient-based factors such as age, ethnicity, and liver disease etiology.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2010.02.076