Structure of the enterococcal T4SS protein PrgL reveals unique dimerization interface in the VirB8 protein family

• Published in: Structure (London) Vol. 30; no. 6; pp. 876 - 885.e5
• Main Authors: Jäger, Franziska, Lamy, Anaïs, Sun, Wei-Sheng, Guerini, Nina, Berntsson, Ronnie P-A
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 02.06.2022
• Subjects: conjugation; type 4 secretion systems; VirB8-like proteins; X-ray crystallography; X-ray crystallography; type 4 secretion systems; conjugation; VirB8-like proteins

Multidrug-resistant bacteria pose serious problems in hospital-acquired infections (HAIs). Most antibiotic resistance genes are acquired via conjugative gene transfer, mediated by type 4 secretion systems (T4SS). Although most multidrug-resistant bacteria responsible for HAIs are of Gram-positive or...