Toll-Like Receptor Signaling Contributes to Proinflammatory Mediator Production in Localized Provoked Vulvodynia

• Published in: Journal of lower genital tract disease Vol. 22; no. 1; p. 52
• Main Authors: Falsetta, Megan L, Foster, David C, Woeller, Collynn F, Pollock, Stephen J, Bonham, Adrienne D, Piekna-Przybylska, Dorota, Maggirwar, Sanjay B, Haidaris, Constantine G, Phipps, Richard P
• Format: Journal Article
• Language: English
• Published: United States 01.01.2018
• Subjects: Aminoquinolines - metabolism; Cells, Cultured; Female; Fibroblasts - immunology; Fibroblasts - metabolism; Gene Expression Profiling; Humans; Imiquimod; Immunity, Innate; Inflammation Mediators - metabolism; Signal Transduction; Toll-Like Receptor 7 - analysis; Toll-Like Receptor 7 - genetics; Vulvodynia - chemically induced; Vulvodynia - pathology

Localized provoked vulvodynia (LPV) afflicts approximately 8% of women in the United States and represents a huge financial, physical, and psychological burden. Women with LPV experience intense pain localized to the vulvar vestibule (area immediately surrounding vaginal opening). We have identified...