Melanin concentrating hormone (MCH): Structure-function aspects of its melanocyte stimulating hormone-like (MSH-like) activity

• Published in: Peptides (New York, N.Y. : 1980) Vol. 10; no. 4; pp. 773 - 778
• Main Authors: Matsunaga, Terry O, Hruby, Victor J, Lebl, Michal, Castrucci, Ana Maria De Lauro, Hadley, Mac E
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.1989
• Subjects: Amino Acid Sequence; Animals; Cell Aggregation - drug effects; Fishes; Hypothalamic Hormones; In Vitro Techniques; Lizards; Melanin concentrating hormone (MCH); Melanins - analysis; Melanins - chemical synthesis; Melanins - pharmacology; Melanocyte stimulating hormone-like activity; Melanocyte-Stimulating Hormones - chemical synthesis; Melanocyte-Stimulating Hormones - pharmacology; Melanocytes - drug effects; Molecular Sequence Data; Peptide Fragments - analysis; Peptide Fragments - chemical synthesis; Peptide Fragments - pharmacology; Pituitary Hormones - chemical synthesis; Pituitary Hormones - pharmacology; Rana pipiens; Skin - drug effects; Skin Pigmentation - drug effects; Stereoisomerism; Structure-Activity Relationship; Structure-function aspects; Melanocyte stimulating hormone-like activity; Melanin concentrating hormone (MCH); Structure-function aspects

Melanin concentrating hormone (MCH) is a heptadecapeptide, Asp-Thr-Met-Arg- Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys -Trp-Glu-Val, synthesized in the brain and secreted from the pars nervosa of teleost fish. This hormone stimulates melanosome (melanin granule) aggregation within integumental melanocy...