C1 Inhibitor Treatment Improves Host Defense in Pneumococcal Meningitis in Rats and Mice

• Published in: The Journal of infectious diseases Vol. 196; no. 1; pp. 115 - 123
• Main Authors: Zwijnenburg, Petra J. G., Poll, Tom van der, Florquin, Sandrine, Polfliet, Machteld M. J., van den Berg, Timo K., Dijkstra, Christine D., Roord, John J., Erik Hack, C., Marceline van Furth, A.
• Format: Journal Article
• Language: English
• Published: United States The University of Chicago Press 01.07.2007; University of Chicago Press
• Subjects: Animal models; Animals; Bacteria; Bacterial meningitis; Blood; Brain - immunology; Brain - pathology; Brain Chemistry; Central nervous system; Cerebrospinal fluid; Cerebrospinal Fluid - microbiology; Chemokines - analysis; Colony Count, Microbial; Complement Activation; Complement C1 - antagonists & inhibitors; Complement C1 Inhibitor Protein - administration & dosage; Complement C1 Inhibitor Protein - pharmacology; Complement Pathway, Classical; Cytokines; Cytokines - analysis; Disease Models, Animal; Humans; Inoculation; Leukocytes; Macrophage-1 Antigen - biosynthesis; Male; Meninges - pathology; Meningitis, Pneumococcal - immunology; Meningitis, Pneumococcal - microbiology; Meningitis, Pneumococcal - pathology; Mice; Mice, Inbred C57BL; Pneumococcal meningitis; Rats; Rats, Wistar; Streptococcus pneumoniae; Streptococcus pneumoniae - isolation & purification

In spite of antibiotic treatment, pneumococcal meningitis continues to be associated with significant morbidity and mortality. The complement system is a key component of innate immunity against invading pathogens. However, activation of complement is also involved in tissue damage, and complement i...